Summary

Name PPP1R9B
Full Name Neurabin-2
Synonyms Neurabin-II, Protein phosphatase 1 regulatory subunit 9B, Spinophilin | PPP1R6
Primary ID Q96SB3
Links - -
Type protein
Relations 7
Function Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAPK1 img/unknown.png phosphorylation PPP1R9B 0.476
Publications: 1 Organism: Homo Sapiens
+ PRKACAdown-regulates activity img/direct_inhibition.png phosphorylation PPP1R9B 0.314
Publications: 1 Organism: Homo Sapiens
+ PPP1R9Bup-regulates activity img/direct-activation.png binding SPATA13 0.496
Publications: 1 Organism: Homo Sapiens
+ PPP1R9Bup-regulates quantity img/direct-activation.png binding TIAM1 0.433
Publications: 1 Organism: Chlorocebus Aethiops
+ PPP1R9Bup-regulates activity img/direct-activation.png binding ARHGEF2 0.405
Publications: 1 Organism: Mus Musculus
+ PPP1R9Bup-regulates activity img/direct-activation.png binding PP1 0.764
Publications: 1 Organism: Homo Sapiens
+ PPP1R9Bup-regulates img/indirect-activation.png F-actin_assembly 0.7
Publications: 1 Organism: Mus Musculus