3.0
Summary
| Name |  UHRF1View Modifications |
| Full Name | E3 ubiquitin-protein ligase UHRF1 |
| Synonyms | Inverted CCAAT box-binding protein of 90 kDa, Nuclear protein 95, Nuclear zinc finger protein Np95, HuNp95, hNp95, RING finger protein 106, Transcription factor ICBP90, Ubiquitin-like PHD and RING finger domain-containing protein 1, hUHRF1, Ubiquitin-like-containing PHD and RING finger domains protein 1 | ICBP90, NP95, RNF106 |
| Primary ID | Q96T88 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PIM1 | down-regulates quantity by destabilization 
phosphorylation
|
UHRF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CyclinB/CDK1 | down-regulates quantity by destabilization
phosphorylation
|
UHRF1 | 0.323 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CDK2 | down-regulates quantity by destabilization
phosphorylation
|
UHRF1 | 0.308 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CSNK1D | up-regulates 
phosphorylation
|
UHRF1 | 0.247 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UHRF1 | down-regulates quantity by repression 
transcriptional regulation
|
ABCB1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM2B | down-regulates quantity by repression
transcriptional regulation
|
UHRF1 | 0.288 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | UHRF1 | down-regulates activity
polyubiquitination
|
RIF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
UHRF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Noncanonical PRC1 | down-regulates quantity by repression
transcriptional regulation
|
UHRF1 | 0.271 |
| Publications: | 1 | Organism: | Mus Musculus | |