| + |
NEU1 | down-regulates activity 
|
ERK1/2 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19151752 |
One of the major molecular changes by NEU1 was decreased sialylation of integrin beta4, assessed by PNA- and MAL-II-lectin blotting of immunoprecipitates with anti-integrin beta4 antibody. The desialylation was accompanied by decreased phosphorylation of the integrin followed by attenuation of focal adhesion kinase and Erk1/2 pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEU1 | up-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260657 |
|
|
Homo sapiens |
YTS-1 Cell |
| pmid |
sentence |
| 32164705 |
Our data showed that NEU1 inhibited cancer cell proliferation, induced apoptosis, and suppressed tumor formation both in vitro and in vivo, by disrupting interaction of FN and integrin β1 and inhibiting the Akt signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEU1 | down-regulates activity 
binding
|
A5/b1 integrin |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260658 |
|
|
Homo sapiens |
YTS-1 Cell |
| pmid |
sentence |
| 32164705 |
NEU1 disrupts FN/ α5β1 interaction. taken together, strongly indicate that overexpressed NEU1 inhibits the Akt pathway by disrupting FN-integrin α5β1 interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEU1 | down-regulates activity
|
AKT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260659 |
|
|
Homo sapiens |
YTS-1 Cell |
| pmid |
sentence |
| 32164705 |
Taken together, these findings indicate that NEU1 overexpression reduces cell proliferation and enhances cell apoptosis through by downregulation of FN-integrin β1-mediated Akt signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFEB | up-regulates quantity by expression
transcriptional regulation
|
NEU1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276544 |
|
|
|
|
| pmid |
sentence |
| 19556463 |
Under aberrant lysosomal storage conditions, TFEB translocated from the cytoplasm to the nucleus, resulting in the activation of its target genes.|Expression analysis of lysosomal genes after TFEB overexpression and silencing. Blue bars show the fold change of the mRNA levels of lysosomal genes in TFEB- versus pcDNA3-transfected cells. |
|
| Publications: |
1 |
| + |
NEU1 | down-regulates activity
|
ITGB4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260655 |
|
|
Homo sapiens |
HT-29 Cell |
| pmid |
sentence |
| 19151752 |
In HT-29 cells cultured with 10% fetal bovine serum (FBS), the phosphorylation of integrin β4 was significantly decreased in NEU1-overexpressing cells and the level seemed to be inversely correlated with the sialidase activity. These results suggest that NEU1 is involved in the regulation of integrin β4 phosphorylation probably through desialylation in colon cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NEU1
- 
- 