+ |
ATR | up-regulates quantity by stabilization
phosphorylation
|
KIFC1 |
0.259 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277296 |
Ser26 |
RPLIKAPsQLPLSGS |
Homo sapiens |
MDA-MB-231 Cell |
pmid |
sentence |
33397932 |
ATM and ATR kinases phosphorylate KIFC1-S26 during DNA-damage conditions.KIFC1 was stabilized upon phosphorylation and thus promoted centrosome clustering, CIN, and tumor recurrence both in vivo and in vitro. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ATM | up-regulates quantity by stabilization
phosphorylation
|
KIFC1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277295 |
Ser26 |
RPLIKAPsQLPLSGS |
Homo sapiens |
MDA-MB-231 Cell |
pmid |
sentence |
33397932 |
ATM and ATR kinases phosphorylate KIFC1-S26 during DNA-damage conditions.KIFC1 was stabilized upon phosphorylation and thus promoted centrosome clustering, CIN, and tumor recurrence both in vivo and in vitro. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CyclinB/CDK1 | up-regulates quantity by stabilization
phosphorylation
|
KIFC1 |
0.433 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266113 |
Ser6 |
sPLLEVKG |
in vitro |
|
pmid |
sentence |
24510915 |
Tryptic digests of KIFC1 treated with CDK1/CYCLIN B were analyzed by LC-MS/MS revealing phosphorylation at Ser6 (Supplementary Fig S5B). These data indicate that phosphorylation by CDK1/CYLCIN B contributes to KIFC1 stability by protecting KIFC1 from APC/C-mediated ubiquitination and subsequent proteasomal degradation. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
CDK1 | up-regulates quantity by stabilization
phosphorylation
|
KIFC1 |
0.47 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277294 |
Ser6 |
sPLLEVKG |
in vitro |
|
pmid |
sentence |
24510915 |
We confirmed that CDK1 phosphorylates Ser6 (Supplementary Fig S5B) and demonstrated that KIFC1 displays CDK1-mediated resistance to ubiquitination by the APC/C (Fig S5C). |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
KIFC1 | up-regulates activity
binding
|
CENPE |
0.554 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266116 |
|
|
Homo sapiens |
SKOV-3 Cell |
pmid |
sentence |
33361741 |
We found that KIFC1 could directly bind to CENPE in SKOV3 cells (Figure 4C, 4D). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
APC-c | down-regulates quantity by destabilization
ubiquitination
|
KIFC1 |
0.26 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266109 |
|
|
in vitro |
|
pmid |
sentence |
24510915 |
Biochemical studies on the kinesins confirmed KIFC1, KIF18A, KIF2C, and KIF4A as APC/C substrates. Furthermore, we showed that the APC/CCDH1-dependent degradation of KIFC1 regulates the bipolar spindle formation and proper cell division. Our in vitro degradation assays showed a time-dependent degradation for four of the five potential substrates tested: KIF18A, KIF2C, KIFC1 and KIF4A were readily degraded in vitro, however remained stable in the presence of either APC/C inhibitor (Fig(Fig4A4A and Supplementary Fig S3A). |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
KIFC1 | up-regulates
|
Cell_migration |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266115 |
|
|
Homo sapiens |
|
pmid |
sentence |
33361741 |
Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KIFC1 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266117 |
|
|
Homo sapiens |
|
pmid |
sentence |
33361741 |
Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KIFC1 | up-regulates
|
Proliferation |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266114 |
|
|
Homo sapiens |
|
pmid |
sentence |
33361741 |
Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer |
|
Publications: |
1 |
Organism: |
Homo Sapiens |