Relation Results

Summary

Name KLF16
Full Name Krueppel-like factor 16
Synonyms Basic transcription element-binding protein 4, BTE-binding protein 4, Novel Sp1-like zinc finger transcription factor 2, Transcription factor BTEB4, Transcription factor NSLP2 | BTEB4, NSLP2
Primary ID Q9BXK1
Links - -
Type protein
Relations 3
Function Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By s ...
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Type: Score: Layout: SPV 
0.2450.20.467SRCKLF16SRC_kinase_familySIN3A

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SRCup-regulates activity img/direct-activation.png phosphorylation KLF16 0.245
Identifier Residue Sequence Organism Cell Line
SIGNOR-276398 Tyr10 AAVACVDyFAADVLM Homo sapiens Ishikawa Cell
pmid sentence
We further confirmed that the Tyr-10 residue of KLF16 is phosphorylated in uterine cells (Fig. 7c). Additional experiments using both pharmacological and dominant negative inhibitors of Src further supported a role for this tyrosine kinase in modulating the activity of KLF16 (Fig. 7, d and f). 
Publications: 1 Organism: Homo Sapiens
+ SRC_kinase_familyup-regulates activity img/direct-activation.png phosphorylation KLF16 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275586 Tyr10 AAVACVDyFAADVLM
pmid sentence
Phosphorylation of KLF16 was confirmed by in vivo (32)P incorporation and controlled by a Y10F site-directed mutant. Inhibition of Src-type tyrosine kinase signaling as well as the nonphosphorylatable Y10F mutation disrupted KLF16-mediated gene silencing, demonstrating that its function is regulatable rather than constitutive.
Publications: 1
+ KLF16up-regulates activity img/direct-activation.png binding SIN3A 0.467
Identifier Residue Sequence Organism Cell Line
SIGNOR-222460 Cricetulus griseus CHO Cell
pmid sentence
detailed biochemical and functional analyses have demonstrated that the TIEG2 _-HRM domain interacts specifically with the PAH2 domain of mSin3A to repress transcription. our data suggest the presence of a conserved _-helical repression motif (_-HRM) in the TIEG and BTEB subfamilies of Sp1-like proteins that mediates transcriptional repression activity through interaction with the corepressor mSin3A.
Publications: 1 Organism: Cricetulus Griseus
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