+ |
SRC_kinase_family | up-regulates activity
phosphorylation
|
KLF16 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275586 |
Tyr10 |
AAVACVDyFAADVLM |
|
|
pmid |
sentence |
22203677 |
Phosphorylation of KLF16 was confirmed by in vivo (32)P incorporation and controlled by a Y10F site-directed mutant. Inhibition of Src-type tyrosine kinase signaling as well as the nonphosphorylatable Y10F mutation disrupted KLF16-mediated gene silencing, demonstrating that its function is regulatable rather than constitutive. |
|
Publications: |
1 |
+ |
SRC | up-regulates activity
phosphorylation
|
KLF16 |
0.246 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-276398 |
Tyr10 |
AAVACVDyFAADVLM |
Homo sapiens |
Ishikawa Cell |
pmid |
sentence |
22203677 |
We further confirmed that the Tyr-10 residue of KLF16 is phosphorylated in uterine cells (Fig. 7c). Additional experiments using both pharmacological and dominant negative inhibitors of Src further supported a role for this tyrosine kinase in modulating the activity of KLF16 (Fig. 7, d and f). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
KLF16 | up-regulates activity
binding
|
SIN3A |
0.476 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-222460 |
|
|
Cricetulus griseus |
CHO Cell |
pmid |
sentence |
11438660 |
detailed biochemical and functional analyses have demonstrated that the TIEG2 _-HRM domain interacts specifically with the PAH2 domain of mSin3A to repress transcription. our data suggest the presence of a conserved _-helical repression motif (_-HRM) in the TIEG and BTEB subfamilies of Sp1-like proteins that mediates transcriptional repression activity through interaction with the corepressor mSin3A. |
|
Publications: |
1 |
Organism: |
Cricetulus Griseus |