| + |
SRC_kinase_family | up-regulates activity 
phosphorylation
|
KLF16 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275586 |
Tyr10 |
AAVACVDyFAADVLM |
|
|
| pmid |
sentence |
| 22203677 |
Phosphorylation of KLF16 was confirmed by in vivo (32)P incorporation and controlled by a Y10F site-directed mutant. Inhibition of Src-type tyrosine kinase signaling as well as the nonphosphorylatable Y10F mutation disrupted KLF16-mediated gene silencing, demonstrating that its function is regulatable rather than constitutive. |
|
| Publications: |
1 |
| + |
SRC_kinase_family | up-regulates activity
phosphorylation
|
KCND3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275566 |
Tyr108 |
GKLHYPRyECISAYD |
|
|
| pmid |
sentence |
| 22198508 |
Our results demonstrate that human atrial I(to) and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue|We found that human atrial I(to) was inhibited by the broad-spectrum PTK inhibitor genistein, the selective epidermal growth factor receptor (EGFR) kinase inhibitor AG556, and the Src-family kinases inhibitor PP2. |
|
| Publications: |
1 |
| + |
SRC_kinase_family | up-regulates quantity
phosphorylation
|
SLC24A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264387 |
Tyr364 |
LAEELGSyGKLKYYD |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 23431067 |
Src family kinase-mediated Tyr-365 phosphorylation of NCKX2 regulates its surface expression. PP2 facilitated the endocytosis of NCKX2 in both the somatodendritic and axonal compartments, suggesting that tyrosine phosphorylation of NCKX2 by SFK negatively regulates its endocytosis. Supporting this idea, activation of SFK enhanced the NCKX activity in the proximal dendrites of dentate granule cells (GCs). These results suggest that endocytosis of somatodendritic NCKX2 is regulated by SFK-dependent phosphorylation of Tyr-365. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIT | up-regulates
phosphorylation
|
SRC_kinase_family |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254995 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15526160 |
Binding of SCF to c-Kit leads to a rapid increase in SFK kinase activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC_kinase_family | up-regulates 
|
Chemotaxis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254996 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15526160 |
The SFK family of tyrosine kinases is named after its prototypic family member c-Src. SCF-induced chemotaxis of Mo7 cells was dependent on SFK activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FCER1 | up-regulates
|
SRC_kinase_family |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254955 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 16470226 |
It is clear that these initial signalling events involve coalescence of the aggregated receptors with specialized microdomains of the plasma membrane known as lipid rafts9, activation of SRC-family kinases and, subsequently, tyrosine phosphorylation of the receptor subunits |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254957 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 16470226 |
It is clear that these initial signalling events involve coalescence of the aggregated receptors with specialized microdomains of the plasma membrane known as lipid rafts9, activation of SRC-family kinases and, subsequently, tyrosine phosphorylation of the receptor subunits |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254963 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 16470226 |
It is clear that these initial signalling events involve coalescence of the aggregated receptors with specialized microdomains of the plasma membrane known as lipid rafts9, activation of SRC-family kinases and, subsequently, tyrosine phosphorylation of the receptor subunits |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SRC_kinase_family | up-regulates
|
Degranulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254956 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16470226 |
So, the association of aggregated FcεRI with the preferentially activated LYN in lipid rafts might be sufficient to shift the equilibrium of FcεRI from a nonphosphorylated state to a phosphorylated state, thereby initiating FcεRI-mediated degranulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SRC_kinase_family