| + |
SIN3A | form complex 
binding
|
MECP2/SIN3A/HDAC complex |
0.824 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267737 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9620804 |
We show that a region of MeCP2 that localizes with the TRD associates with a corepressor complex containing the transcriptional repressor mSin3A and histone deacetylases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIN3A | down-regulates quantity by repression 
transcriptional regulation
|
KLK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253663 |
|
|
|
|
| pmid |
sentence |
| 16254079 |
Chromatin immunoprecipitation (ChIP) and DNA affinity precipitation analysis demonstrated that Ebp1 and Sin3A associate at the PSA and E2F1 promoters. Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes. |
|
| Publications: |
1 |
| + |
KLF11 | up-regulates activity 
binding
|
SIN3A |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222344 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 11438660 |
detailed biochemical and functional analyses have demonstrated that the TIEG2 _-HRM domain interacts specifically with the PAH2 domain of mSin3A to repress transcription. our data suggest the presence of a conserved _-helical repression motif (_-HRM) in the TIEG and BTEB subfamilies of Sp1-like proteins that mediates transcriptional repression activity through interaction with the corepressor mSin3A. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
KLF16 | up-regulates activity
binding
|
SIN3A |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222460 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 11438660 |
detailed biochemical and functional analyses have demonstrated that the TIEG2 _-HRM domain interacts specifically with the PAH2 domain of mSin3A to repress transcription. our data suggest the presence of a conserved _-helical repression motif (_-HRM) in the TIEG and BTEB subfamilies of Sp1-like proteins that mediates transcriptional repression activity through interaction with the corepressor mSin3A. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
KLF10 | up-regulates activity
binding
|
SIN3A |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222394 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 11438660 |
detailed biochemical and functional analyses have demonstrated that the TIEG2 _-HRM domain interacts specifically with the PAH2 domain of mSin3A to repress transcription. our data suggest the presence of a conserved _-helical repression motif (_-HRM) in the TIEG and BTEB subfamilies of Sp1-like proteins that mediates transcriptional repression activity through interaction with the corepressor mSin3A. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
NFX1 | up-regulates activity
binding
|
SIN3A |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226360 |
|
|
Homo sapiens |
HFK Cell |
| pmid |
sentence |
| 18505829 |
we investigated the mechanism of NFX1-91 repression of the hTERT promoter and demonstrated that NFX1-91 interacts with the corepressor mSin3A/HDAC to maintain the deacetylated status at the hTERT promoter, thus providing a mechanism by which NFX1-91 represses hTERT expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF9 | up-regulates activity
binding
|
SIN3A |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222434 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 11438660 |
detailed biochemical and functional analyses have demonstrated that the TIEG2 _-HRM domain interacts specifically with the PAH2 domain of mSin3A to repress transcription. our data suggest the presence of a conserved _-helical repression motif (_-HRM) in the TIEG and BTEB subfamilies of Sp1-like proteins that mediates transcriptional repression activity through interaction with the corepressor mSin3A. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
PHF12 | up-regulates activity
binding
|
SIN3A |
0.782 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266995 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11390640 |
Pf1 interacts with mSin3A in vivo. Gal4-Pf1 repressed activity of the reporter gene fivefold relative to Gal4 alone (Fig. (Fig.5A),5A), suggesting that DNA-bound Pf1 was capable of recruiting functional mSin3A complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLF13 | up-regulates activity
binding
|
SIN3A |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-222437 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 11438660 |
detailed biochemical and functional analyses have demonstrated that the TIEG2 _-HRM domain interacts specifically with the PAH2 domain of mSin3A to repress transcription. our data suggest the presence of a conserved _-helical repression motif (_-HRM) in the TIEG and BTEB subfamilies of Sp1-like proteins that mediates transcriptional repression activity through interaction with the corepressor mSin3A. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
SIN3A | down-regulates quantity by repression 
transcriptional regulation
|
TERT |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226363 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18505829 |
We investigated the mechanism of NFX1-91 repression of the hTERT promoter and demonstrated that NFX1-91 interacts with the corepressor mSin3A/HDAC to maintain the deacetylated status at the hTERT promoter, thus providing a mechanism by which NFX1-91 represses hTERT expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SIN3A
- 
- 