Summary

Name NUAK2
Full Name NUAK family SNF1-like kinase 2
Synonyms Omphalocele kinase 2, SNF1/AMP kinase-related kinase, SNARK | OMPHK2, SNARK
Primary ID Q9H093
Links - -
Type protein
Relations 3
Function Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation LATS1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NUAK2 0.279
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation WDR45 0.267
Publications: 1 Organism: Homo Sapiens