+ |
NUAK2 | down-regulates
phosphorylation
|
LATS1 |
0.31 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-161796 |
Ser464 |
NIPVRSNsFNNPLGN |
Homo sapiens |
|
pmid |
sentence |
19927127 |
Phosphorylation at ser-464 by nuak1 and nuak2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
STK11 | up-regulates
phosphorylation
|
NUAK2 |
0.279 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-122717 |
Thr208 |
HQGKFLQtFCGSPLY |
Homo sapiens |
|
pmid |
sentence |
14976552 |
A total of 12 human kinases (nuak1, nuak2, brsk1, brsk2, qik, qsk, sik, mark1, mark2, mark3, mark4 and melk) are related to ampk. Here we demonstrate that lkb1 can phosphorylate the t-loop of all the members of this subfamily, apart from melk, increasing their activity >50-fold. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NUAK2 | up-regulates activity
phosphorylation
|
WDR45 |
0.267 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268481 |
|
|
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
28561066 |
WIPI4 is stimulated by AMPK, NUAK2 and BRSK2. This finding is supported by the results of our kinome screening, which identified AMPK and the AMKP-related kinases NUAK2 and BRSK2, all of which function downstream of LKB1 (ref. 69) and stimulate the localization of WIPI4 to nascent autophagosomes. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |