| + |
MAPK8 | up-regulates quantity by stabilization 
phosphorylation
|
CDT1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276361 |
Ser391 |
LRSAAPSsPGSPRPA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21930785 |
We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G(2) phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276360 |
Ser491 |
GSCCTIMsPGEMEKH |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21930785 |
We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G(2) phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
p38 | up-regulates quantity by stabilization
phosphorylation
|
CDT1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276362 |
Ser391 |
LRSAAPSsPGSPRPA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21930785 |
We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G(2) phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276363 |
Ser491 |
GSCCTIMsPGEMEKH |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21930785 |
We discovered that human Cdt1, an essential origin licensing protein whose activity must be restricted to G(1) phase, is a substrate of the stress-activated mitogen-activated protein (MAP) kinases p38 and c-Jun N-terminal kinase (JNK). These MAP kinases phosphorylate Cdt1 both during unperturbed G(2) phase and during an acute stress response. Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after DNA damage by blocking Cdt1 binding to the Cul4 adaptor, Cdt2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDT1 | up-regulates activity
binding
|
CDT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261682 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14672932 |
We further show that Cdc6 physically associates with Cdt1 via its N-terminal noncatalytic domain, a region we had previously shown to be essential for Cdc6 function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDT1 | up-regulates activity
binding
|
MCM |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261679 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14672932 |
Chromosomal DNA replication requires the recruitment of the six-subunit minichromosome maintenance (Mcm) complex to chromatin through the action of Cdc6 and Cdt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKP2 | down-regulates quantity by destabilization 
binding
|
CDT1 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272565 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10790373 |
Biochemical studies showed that Skp2 interacts specifically with cyclin E and thereby promotes its ubiquitylation and degradation both in vivo and in vitro. These results suggest that specific degradation of cyclin E and p27(Kip1) is mediated by the SCF(Skp2) ubiquitin ligase complex, and that Skp2 may control chromosome replication and centrosome duplication by determining the abundance of cell cycle regulators. Skp2 was associated with Cul1, but not Cul3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin4-RBX1-DDB1 | down-regulates quantity by destabilization
polyubiquitination
|
CDT1 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272810 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14578910 |
We show that radiation-mediated CDT1 proteolysis is independent of ATM and CHK2 and can occur in G1-phase cells. Loss of the COP9-signalosome (CSN) or CUL4-ROC1 complexes completely suppresses CDT1 proteolysis. CDT1 is specifically polyubiquitinated by CUL4 complexes and the interaction between CDT1 and CUL4 is regulated in part by gamma-irradiation. Our study reveals an evolutionarily conserved and uncharacterized G1 checkpoint that induces CDT1 proteolysis by the CUL4-ROC1 ubiquitin E3 ligase and CSN complexes in response to DNA damage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
CDT1 |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272568 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10790373 |
Biochemical studies showed that Skp2 interacts specifically with cyclin E and thereby promotes its ubiquitylation and degradation both in vivo and in vitro. These results suggest that specific degradation of cyclin E and p27(Kip1) is mediated by the SCF(Skp2) ubiquitin ligase complex, and that Skp2 may control chromosome replication and centrosome duplication by determining the abundance of cell cycle regulators. Skp2 was associated with Cul1, but not Cul3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GMNN | down-regulates activity
binding
|
CDT1 |
0.972 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261680 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 11125146 |
Here we show that geminin interacts tightly with Cdt1, a recently identified replication initiation factor necessary for MCM loading. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDT1 | up-regulates activity
binding
|
MCM2 |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261681 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14672932 |
Chromosomal DNA replication requires the recruitment of the six-subunit minichromosome maintenance (Mcm) complex to chromatin through the action of Cdc6 and Cdt1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDT1
- 
- 