Summary

Name FZD8
Full Name Frizzled-8
Synonyms Fz-8, hFz8
Primary ID Q9H461
Links - -
Type protein
Relations 6
Function Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

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Relations

Regulator Mechanism target score ℹ
+ WNT1up-regulates img/direct-activation.png binding FZD8 0.714
Publications: 1 Organism: Homo Sapiens
+ FZD8up-regulates activity img/direct-activation.png binding LRP5 0.717
Publications: 1 Organism: Homo Sapiens
+ ZNRF3down-regulates quantity img/direct_inhibition.png ubiquitination FZD8 0.52
Publications: 1 Organism: Homo Sapiens
+ RYKup-regulates img/direct-activation.png binding FZD8 0.699
Publications: 1 Organism: Homo Sapiens
+ WNT3Aup-regulates img/direct-activation.png binding FZD8 0.79
Publications: 1 Organism: Homo Sapiens
+ FZD8up-regulates activity img/direct-activation.png binding LRP6 0.745
Publications: 1 Organism: Homo Sapiens