| + |
PTPRK | up-regulates activity 
dephosphorylation
|
ZNRF3 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260110 |
|
|
Homo sapiens |
NCI-H1703 Cell |
| pmid |
sentence |
| 31934854 |
We show that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt signaling promoting Wnt receptor degradation, which is also expressed in the organizer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RSPO1 | down-regulates 
relocalization
|
ZNRF3 |
0.796 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199629 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
This is counteracted by respondin 1, which induces znrf3 internalization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates quantity by destabilization
ubiquitination
|
FZD2 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197414 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates
ubiquitination, relocalization
|
FZD2 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197417 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22575959 |
Znrf3 is associated with the wnt receptor complex, and inhibits wntby promoting the turnover of frizzled and lrp6. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199650 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Znrf3 is associated with the wnt receptor complex, and inhibits wntby promoting the turnover of frizzled and lrp6. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates quantity
ubiquitination
|
FZD4 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260115 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates quantity
ubiquitination
|
FZD8 |
0.52 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260111 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates quantity
ubiquitination
|
LRP6 |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260112 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates quantity
ubiquitination
|
FZD5 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260118 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates quantity
ubiquitination
|
FZD6 |
0.597 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260114 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RSPO1 | down-regulates quantity
relocalization
|
ZNRF3 |
0.796 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260113 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22575959 |
Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3. These data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
ZNRF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNRF3 | down-regulates
ubiquitination
|
LRP6 |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197420 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22575959 |
Znrf3 is associated with the wnt receptor complex, and inhibits wnt by promoting the turnover of frizzled and lrp6. Frizzled receptors are regu__lated by cycles of ubiquitylation and deubiquitylation, and znrf3 and rnf43 act as frizzled ubiquitin ligases, removing frizzled and possibly lrp6 from the plasma membrane. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Znrf3 is associated with the wnt receptor complex, and inhibits wnt by promoting the turnover of frizzled and lrp6. Frizzled receptors are regu__lated by cycles of ubiquitylation and deubiquitylation, and znrf3 and rnf43 act as frizzled ubiquitin ligases, removing frizzled and possibly lrp6 from the plasma membrane. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
ZNRF3
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