Summary

Name DEF6
Full Name Differentially expressed in FDCP 6 homolog
Synonyms DEF-6, IRF4-binding protein | IBP
Primary ID Q9H4E7
Links - -
Type protein
Relations 6
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation DEF6 0.2
Publications: 3 Organism: Homo Sapiens, In Vitro
+ up-regulates activity img/direct-activation.png binding RAP1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAP1B 0.14
Publications: 1 Organism: Homo Sapiens