3.0
Summary
| Name |  NHEJ1View Modifications |
| Full Name | Non-homologous end-joining factor 1 |
| Synonyms | Protein cernunnos, XRCC4-like factor | XLF |
| Primary ID | Q9H9Q4 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17470781). Binds DNA in a length-dependent manner (PubMed:17317666). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKDC |
phosphorylation
|
NHEJ1 | 0.654 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATM |
phosphorylation
|
NHEJ1 | 0.574 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SCF-betaTRCP | down-regulates quantity by destabilization 
ubiquitination
|
NHEJ1 | 0.329 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | down-regulates quantity by destabilization
phosphorylation
|
NHEJ1 | 0.367 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NHEJ1 | up-regulates activity 
binding
|
Lig4-Xrcc4 complex | 0.826 |
| Publications: | 1 | Organism: | Homo Sapiens | |