+ |
AMPK | down-regulates
phosphorylation
|
MLXIPL |
0.406 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-216526 |
Ser556 |
LLRSPGsPQETVPE |
Rattus norvegicus |
|
pmid |
sentence |
11724780 |
These results strongly suggested that the fatty acid inhibition of glucose-induced l-PK transcription resulted from AMPK phosphorylation of ChREBP at Ser568, which inactivated the DNA binding activity. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-216561 |
|
|
Rattus norvegicus |
|
pmid |
sentence |
21892142 |
AMPK has also been suggested to phosphorylate the glucose-sensitive transcription factor ChREBP89 which dictates expression of an overlapping lipogenic gene signature with Srebp1 |
|
Publications: |
2 |
Organism: |
Rattus Norvegicus |
+ |
PRKAA1 | down-regulates
phosphorylation
|
MLXIPL |
0.428 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-112289 |
|
|
Homo sapiens |
|
pmid |
sentence |
11724780 |
Ampk has also been suggested to phosphorylate the glucose-sensitive transcription factor chrebpthe dna binding activity, as assayed in a gel-shift assay of the truncated chrebp, was gradually inactivated with time by treatment with ampk |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-176494 |
|
|
Homo sapiens |
|
pmid |
sentence |
21892142 |
Ampk has also been suggested to phosphorylate the glucose-sensitive transcription factor chrebpthe dna binding activity, as assayed in a gel-shift assay of the truncated chrebp, was gradually inactivated with time by treatment with ampk |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
MLXIPL | up-regulates quantity by expression
transcriptional regulation
|
FAS |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267947 |
|
|
Mus musculus |
|
pmid |
sentence |
15496471 |
The present study provides evidence for a direct and dominant role of ChREBP in the glucose regulation of two key liver lipogenic enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Tissue: |
Liver |
+ |
MLXIPL | up-regulates quantity by expression
transcriptional regulation
|
ELOVL6 |
0.409 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267945 |
|
|
Homo sapiens |
Hep-G2 Cell |
pmid |
sentence |
27524233 |
In this study, we clearly show that mouse and human Elovl6 are direct targets of ChREBP. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
14-3-3 | down-regulates activity
relocalization
|
MLXIPL |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255667 |
|
|
Rattus norvegicus |
|
pmid |
sentence |
26984404 |
AMP inhibits the nuclear localization of ChREBP through an allosteric activation of ChREBP/14-3-3 interactions |
|
Publications: |
1 |
Organism: |
Rattus Norvegicus |
+ |
SIK2 | down-regulates
|
MLXIPL |
0.33 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265746 |
|
|
Mus musculus |
|
pmid |
sentence |
24841198 |
Moreover, SIK2 was shown to down-regulate the carbohydrate-responsive element-binding protein (ChREBP)-mediated lipogenesis in hepatocytes through the inhibitory phosphorylation of p300/Ser89 and to prevent steatosis in mice |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
AMP | down-regulates activity
chemical inhibition
|
MLXIPL |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255668 |
|
|
Rattus norvegicus |
|
pmid |
sentence |
26984404 |
We discovered that protein-free extracts of high fat-fed livers contained, in addition to ketone bodies, a new metabolite, identified as AMP, which specifically activates the interaction between ChREBP and 14-3-3. |
|
Publications: |
1 |
Organism: |
Rattus Norvegicus |
+ |
MLXIPL | up-regulates quantity by expression
transcriptional regulation
|
ACACA |
0.448 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267946 |
|
|
Mus musculus |
|
pmid |
sentence |
15496471 |
The present study provides evidence for a direct and dominant role of ChREBP in the glucose regulation of two key liver lipogenic enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Tissue: |
Liver |