| + |
FASLG | up-regulates activity 
binding
|
FAS |
0.9 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216292 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14965271 |
Fas (CD95) is activated by its natural ligand FasL |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49688 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9228058 |
The death-inducing receptor fas is activated when cross-linked by the type ii membrane protein faslg (fasl) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS |
| + |
FAS | up-regulates 
|
RASSF1 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198435 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22830020 |
It was also shown that the fas active receptor induces rassf1a to compete with raf1 in binding to mst2, thus promoting the formation of a lats1 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates 
|
FAS |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252473 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15004527 |
Akt may serve to stimulate certain proteins (e.g., Ikk) involved in the prevention of apoptosis such as nf-kb as well as repress other proteins normally involved in the induction of apoptosis such as the forkhead transcription factors (fkhr, now know as foxo3), creb, glycogen synthetase-3 kinase-beta (gsk-3beta), fas, caspase-9 and cell cycle inhibitors such as p27 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53 | up-regulates quantity by expression
transcriptional regulation
|
FAS |
0.589 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62376 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 9841917 |
In an attempt to understand how CD95 expression is regulated by p53, we identified a p53-responsive element within the first intron of the CD95 gene, as well as three putative elements within the promoter. The intronic element conferred transcriptional activation by p53 and cooperated with p53-responsive elements in the promoter of the CD95 gene. wt p53 bound to and transactivated the CD95 gene, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Mitochondrial Control of Apoptosis |
| + |
DAXX | down-regulates 
binding
|
FAS |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49473 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9215629 |
A c-terminal portion of daxx interacts with the fas death domain. The fas-binding domain of daxx is a dominant-negative inhibitor of both fas-induced apoptosis and jnk activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAS | up-regulates activity
binding
|
RIPK1 |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235430 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 7538908 |
Fas associates with rip. Rip is a novel form of apoptosis-inducing protein |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical |
| + |
FAS | up-regulates activity
binding
|
FAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85991 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
The fas receptor, upon binding to the fasl, trimerizes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217809 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 19305384 |
Fas/FasL, TRAIL/DR4, TRAIL/DR5 and TNF-alpha/TNFR1 are ligand/receptor pairs of the tumor necrosis factor/nerve growth factor family, which are able to induce apoptosis by trimerization of the receptor by its corresponding ligand. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS |
| + |
FAS | up-regulates
binding
|
MAP3K5 |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11495919 |
Ask1 binds fas |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FAS | up-regulates activity
binding
|
FADD |
0.907 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176651 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21959933 |
Aggregation-induced conformational changes in fas lead to the formation of the death-inducing signalling complex (disc) which involves recruitment of the adaptor protein fadd/mort1 through a homotypic interaction of death domains, present in both the intracellular region of fas and the c-terminus of fadd. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS |
| + |
FAS | up-regulates
|
DAXX |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60167 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9743501 |
Fas activation induced daxx to interact with ask1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLXIPL | up-regulates quantity by expression
transcriptional regulation
|
FAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267947 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15496471 |
The present study provides evidence for a direct and dominant role of ChREBP in the glucose regulation of two key liver lipogenic enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Liver |
| + |
EGR1 | down-regulates quantity by repression
transcriptional regulation
|
FAS |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254278 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9300687 |
Thus, Egr-1 seems to control the expression of downstream target genes not only as a transcriptional activator, but also as a repressor molecule. In B cells, Egr-1 therefore plays a critical role in integrating the short-lived signal delivered by triggering of the Ag receptor into phenotypic changes, including repression of CD95 and CD23 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | down-regulates
|
FAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123239 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15004527 |
Akt may serve to stimulate certain proteins (e.g., Ikk) involved in the prevention of apoptosis such as nf-kb as well as repress other proteins normally involved in the induction of apoptosis such as the forkhead transcription factors (fkhr, now know as foxo3), creb, glycogen synthetase-3 kinase-beta (gsk-3beta), fas, caspase-9 and cell cycle inhibitors such as p27 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |
| + |
RIPK1 | up-regulates activity
binding
|
FAS |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18545270 |
The death domain of the rip1 kinase binds to death receptors such as fas that is required for caspase 8 activation and apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical |
3.0
FAS
- 
- 