| + |
PRKCZ | up-regulates quantity by stabilization 
phosphorylation
|
PARD6A |
0.835 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276433 |
Ser345 |
RGDGSGFsL |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 23249950 |
APKC associates and phosphorylates Par6 on S345. aPKC expression stabilizes Par6 protein levels. We show that the aPKC, PKCι, interacts with TGF-β receptors through Par6 and that these proteins localize to the leading edge of migrating cells. Furthermore, Par6 phosphorylation on serine 345 by TGF-β receptors is enhanced in the presence of aPKC. aPKC kinase activity, as well as an association with Par6, were found to be important for Par6 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFBR2 | up-regulates
phosphorylation
|
PARD6A |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200193 |
Ser345 |
RGDGSGFsL |
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 23249950 |
Transforming growth factor ? (tgf-?) Has been shown to regulate cell plasticity through the phosphorylation of par6 on a conserved serine residue (s345) by the type ii tgf-? Receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227484 |
Ser345 |
RGDGSGFsL |
Homo sapiens |
NMuMg Cell |
| pmid |
sentence |
| 15761148 |
We demonstrate that Par6, a regulator of epithelial cell polarity and tight-junction assembly, interacts with TGFbeta receptors and is a substrate of the type II receptor, TbetaRII. [...] These data suggest that T_RII phosphorylates Par6 at its penultimate residue, Ser345. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKCI | up-regulates quantity by stabilization
phosphorylation
|
PARD6A |
0.86 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276432 |
Ser345 |
RGDGSGFsL |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 23249950 |
APKC associates and phosphorylates Par6 on S345. aPKC expression stabilizes Par6 protein levels. We show that the aPKC, PKCι, interacts with TGF-β receptors through Par6 and that these proteins localize to the leading edge of migrating cells. Furthermore, Par6 phosphorylation on serine 345 by TGF-β receptors is enhanced in the presence of aPKC. aPKC kinase activity, as well as an association with Par6, were found to be important for Par6 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PARD6A | form complex 
binding
|
PARD6/SMURF1 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227559 |
|
|
Homo sapiens |
NMuMg Cell |
| pmid |
sentence |
| 15761148 |
The Par6-Smurf1 complex then mediates the localized ubiquitination of RhoA to enable the TGF_-dependent dissolution of tight junctions during EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL2 | up-regulates
binding
|
PARD6A |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
In pcp , dvl binds to proteins such as pkc, atypical pkc (apkc), dvl-associated activator of morphogenesis 1 (daam1), dvl-associating protein with a high frequency of leu residues (daple) and partitioning defective 6 (par6), which are important for the regulation of small gtpases such as rho and rac and, consequently, the cytoskeleton and cell polarity58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PARD6A | up-regulates activity
binding
|
PRKCA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227489 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22544755 |
The Par complex member Par-6, previously thought to inhibit aPKC, is a potent activator of aPKC in our assays. Par-6 and aPKC interact via PB1 domain heterodimerization, and this interaction activates aPKC by displacing the pseudosubstrate, although full activity requires the Par-6 CRIB-PDZ domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PARD6A | up-regulates 
|
RAC1 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199530 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
In pcp , dvl binds to proteins such as pkc, atypical pkc (apkc), dvl?associated Activator of morphogenesis 1 (daam1), dvl-associating protein with a high frequency of leu residues (daple) and partitioning defective 6 (par6), which are important for the regulation of small gtpases such as rho and rac and, consequently, the cytoskeleton and cell polarity58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PARD6A
- 
- 