Summary

Name INCENP
Full Name Inner centromere protein
Synonyms INCE_HUMAN
Primary ID Q9NQS7
Links - -
Type protein
Relations 7
Function Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation INCENP 1.00
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation INCENP 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AURKB 1.00
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation INCENP
Publications: 1 Organism: Drosophila Melanogaster
+ up-regulates activity img/direct-activation.png binding AURKA
Publications: 1 Organism: Drosophila Melanogaster