4.0
Summary
| Name |  INCENPView Modifications |
| Full Name | Inner centromere protein |
| Synonyms | INCE_HUMAN |
| Primary ID | Q9NQS7 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AURKB | up-regulates 
phosphorylation
|
INCENP | 0.974 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | CHEK2 | up-regulates activity
phosphorylation
|
INCENP | 0.261 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates
phosphorylation
|
INCENP | 0.757 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | INCENP | up-regulates activity
binding
|
AURKA | 0.695 |
| Publications: | 1 | Organism: | Drosophila Melanogaster | |
| + | AURKA | up-regulates activity
phosphorylation
|
INCENP | 0.695 |
| Publications: | 1 | Organism: | Drosophila Melanogaster | |
| + | INCENP | form complex 
binding
|
CPC | 0.877 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | INCENP | up-regulates
binding
|
AURKB | 0.974 |
| Publications: | 1 | Organism: | Homo Sapiens | |