Summary

Name RNF216
Full Name E3 ubiquitin-protein ligase RNF216
Synonyms RING finger protein 216, RING-type E3 ubiquitin transferase RNF216, Triad domain-containing protein 3, Ubiquitin-conjugating enzyme 7-interacting protein 1, Zinc finger protein inhibiting NF-kappa-B | TRIAD3, UBCE7IP1, ZIN
Primary ID Q9NWF9
Links - -
Type protein
Relations 7
Function Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.

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Relations

Regulator Mechanism target score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF216 0.2
Publications: 1 Organism: Homo Sapiens
+ RNF216down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RIPK1 0.518
Publications: 1 Organism: Homo Sapiens
+ RNF216down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TIRAP 0.396
Publications: 1 Organism: Homo Sapiens
+ RNF216down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TLR8 0.26
Publications: 1 Organism: Homo Sapiens
+ RNF216down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TICAM1 0.362
Publications: 1 Organism: Homo Sapiens
+ RNF216down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TLR4 0.397
Publications: 1 Organism: Homo Sapiens
+ RNF216down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TLR9 0.415
Publications: 1 Organism: Homo Sapiens