| + |
KLHL9 | down-regulates quantity by destabilization 
binding
|
CEBPB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272458 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 25303533 |
KLHL9 mediates poly-ubiquitylation of C/EBPβ and C/EBPδ isoforms. We confirmed KLHL9 deletions in an independent cohort and showed that this protein is necessary for Cul3-ligase mediated ubiquitylation and proteasomal degradation of established MES-GBM MRs, C/EBPβ and C/EBPδ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLHL9 | up-regulates activity 
binding
|
AURKB |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271658 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17543862 |
Aurora B Interacts with the Cul3 Complex during Mitosis and Is Ubiquitylated in a Cul3-Dependent Manner In Vivo and In Vitro. our results suggest that Cul3/KLHL9/KLHL13 activity is required to remove the chromosomal passenger protein Aurora B from mitotic chromosomes, and that Aurora B is ubiquitylated in vivo and in vitro in a KLHL9/13-dependent manner. We conclude that the Cul3/KLHL9/KLHL13 E3 ligase is an important cell-cycle regulator which, in addition to the anaphase-promoting complex (APC), coordinates mitotic progression and completion of cytokinesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLHL9 | up-regulates activity
binding
|
Cullin 3-RBX1-Skp1 |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271660 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17543862 |
Aurora B Interacts with the Cul3 Complex during Mitosis and Is Ubiquitylated in a Cul3-Dependent Manner In Vivo and In Vitro. our results suggest that Cul3/KLHL9/KLHL13 activity is required to remove the chromosomal passenger protein Aurora B from mitotic chromosomes, and that Aurora B is ubiquitylated in vivo and in vitro in a KLHL9/13-dependent manner. We conclude that the Cul3/KLHL9/KLHL13 E3 ligase is an important cell-cycle regulator which, in addition to the anaphase-promoting complex (APC), coordinates mitotic progression and completion of cytokinesis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272455 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 25303533 |
KLHL9 mediates poly-ubiquitylation of C/EBPβ and C/EBPδ isoforms. We confirmed KLHL9 deletions in an independent cohort and showed that this protein is necessary for Cul3-ligase mediated ubiquitylation and proteasomal degradation of established MES-GBM MRs, C/EBPβ and C/EBPδ. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KLHL9 | down-regulates quantity by destabilization
binding
|
CEBPD |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272459 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 25303533 |
KLHL9 mediates poly-ubiquitylation of C/EBPβ and C/EBPδ isoforms. We confirmed KLHL9 deletions in an independent cohort and showed that this protein is necessary for Cul3-ligase mediated ubiquitylation and proteasomal degradation of established MES-GBM MRs, C/EBPβ and C/EBPδ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KLHL9
- 
- 