| + |
CSNK2A1 | up-regulates activity 
phosphorylation
|
CEBPD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276886 |
Ser57 |
PAMYDDEsAIDFSAY |
in vitro |
|
| pmid |
sentence |
| 25680545 |
Here, we have identified the CCAAT/enhancer binding protein δ (C/EBPδ) as a new substrate for CK2. Using point mutants of C/EBPδ the major phosphorylation site for CK2 was mapped to serine 57, which is located within the transactivation domain of C/EBPδ. For proper functioning as a transcription factor C/EBPδ has to be translocated into the nucleus where it forms heterodimers with other members of the C/EBP family of proteins and ATF4. Here, we found that CK2 phosphorylation does neither influence the subcellular localization of C/EBPδ nor its interaction with C/EBPβ, but rather does CK2 phosphorylation modulate the transcriptional activity of C/EBPδ. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CEBPD | up-regulates quantity by expression 
transcriptional regulation
|
CCL20 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254056 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 23028973 |
CEBPD activated in macrophages played a functional role in promoting the tube formation of endothelial cells and the migration and proliferation of synoviocytes. In vivo DNA binding assays and reporter assays showed that CEBPD up-regulated CCL20, CXCL1, IL23A and TNFAIP6 transcripts through direct binding to their promoter regions. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
SOD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253774 |
|
|
Homo sapiens |
Urinary Bladder Cancer Cell Line |
| pmid |
sentence |
| 20385105 |
Expression of CEBPD reduced cisplatin-induced reactive oxygen species (ROS) and apoptosis in NTUB1 cells by inducing the expression of Cu/Zn-superoxide dismutase (SOD1) via direct promoter transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KLHL9 | down-regulates quantity by destabilization 
binding
|
CEBPD |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272459 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 25303533 |
KLHL9 mediates poly-ubiquitylation of C/EBPβ and C/EBPδ isoforms. We confirmed KLHL9 deletions in an independent cohort and showed that this protein is necessary for Cul3-ligase mediated ubiquitylation and proteasomal degradation of established MES-GBM MRs, C/EBPβ and C/EBPδ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
MSTN |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255332 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24011072 |
To identify whether p-Stat3 acts through C/EBPδ to stimulate myostatin, we knocked down C/EBPδ using siRNA. In this case, the IL-6-induced increase in myostatin expression was blocked when C/EBPδwas suppressed even though p-Stat3 was increased |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
TNFAIP6 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254057 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 23028973 |
CEBPD activated in macrophages played a functional role in promoting the tube formation of endothelial cells and the migration and proliferation of synoviocytes. In vivo DNA binding assays and reporter assays showed that CEBPD up-regulated CCL20, CXCL1, IL23A and TNFAIP6 transcripts through direct binding to their promoter regions. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
CXCL1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254060 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 23028973 |
CEBPD activated in macrophages played a functional role in promoting the tube formation of endothelial cells and the migration and proliferation of synoviocytes. In vivo DNA binding assays and reporter assays showed that CEBPD up-regulated CCL20, CXCL1, IL23A and TNFAIP6 transcripts through direct binding to their promoter regions. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
KLF5 |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210007 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16054042 |
Klf5 expression is induced by c/ebpbeta and delta. KLF5, in turn, acts in concert with c/ebpbeta/delta to activate the ppargamma2 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
IL23A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254061 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 23028973 |
CEBPD activated in macrophages played a functional role in promoting the tube formation of endothelial cells and the migration and proliferation of synoviocytes. In vivo DNA binding assays and reporter assays showed that CEBPD up-regulated CCL20, CXCL1, IL23A and TNFAIP6 transcripts through direct binding to their promoter regions. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NR3C1 | up-regulates quantity
transcriptional regulation
|
CEBPD |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251648 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 1840554 |
The expression levels of both C/EBPB and C/EBPD are increased dramatically during the time of hormonal stimulation (see Fig. 8). Furthermore, the C/EBPB- and C/EBPD encoding genes are activated directly by adipogenic hormones |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253061 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 10649448 |
We conclude that glucocorticoid-induced adipogenesis from bone marrow stromal cells is mediated through a reaction cascade in which dexamethasone transcriptionally activates C/EBPδ; C/EBPδ then binds to PPARγ2 promoter and transactivates PPARγ2 gene expression. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
CEBPD |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255333 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24011072 |
To assess whether Stat3 affects C/EBPδ expression, we co-transfected C2C12 myoblasts with a plasmid expressing a C/EBPδpromoter-driven luciferase plus a lentivirus expressing the constitutively active Stat3C-GFP. Overexpression of Stat3C increased C/EBPδpromoter activity compared to that in lentivirus expressing GFP control |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255334 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25787076 |
P-Stat3 stimulates C/EBPδ expression and activity, which increases myostatin and MAFbx/Atrogin-1 and MuRF-1. Both pathways result in protein losses in muscle. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
Cullin 3-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
CEBPD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272457 |
|
|
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 25303533 |
KLHL9 mediates poly-ubiquitylation of C/EBPβ and C/EBPδ isoforms. We confirmed KLHL9 deletions in an independent cohort and showed that this protein is necessary for Cul3-ligase mediated ubiquitylation and proteasomal degradation of established MES-GBM MRs, C/EBPβ and C/EBPδ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253062 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 10649448 |
We conclude that glucocorticoid-induced adipogenesis from bone marrow stromal cells is mediated through a reaction cascade in which dexamethasone transcriptionally activates C/EBPdelta; C/EBPdelta then binds to PPARgamma2 promoter and transactivates PPARgamma2 gene expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
SMAD3/SMAD4 | down-regulates
binding
|
CEBPD |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97120 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12524424 |
C/ebpbeta and c/ebpdelta were found to physically interact with smad3 and smad4, and smad3 cooperated with smad4 and tgf-beta signaling to repress the transcriptional activity of c/ebps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | down-regulates quantity by repression
transcriptional regulation
|
CEBPD |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184283 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19254573 |
Sox9 directly binds to the promoter regions of c/ebpbeta and c/ebpdelta to suppress their promoter activity, preventing adipocyte differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
dexamethasone | up-regulates quantity by expression
|
CEBPD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43254 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8754811 |
The differentiation of 3t3 preadipocytes into adipocytes is accompanied by a transient induction of c/ebpbeta and c/ebpdelta expression in response to treatment of the cells with methylisobutylxanthine (mix) and dexamethasone (dex), respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CEBPD
- 
- 