Name	POLL View Modifications
Full Name	DNA polymerase lambda
Synonyms	Pol Lambda, EC 2.7.7.7, EC 4.2.99.-, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa \|
Primary ID	Q9UGP5
Links	- -
Type	protein
Relations	8
Function	DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). {ECO:0000269\|PubMed:10887191, ECO:0000269\|PubMed:10982892, ECO:0000269\|PubMed:11457865, ECO:0000269\|PubMed:12809503, ECO:0000269\|PubMed:14627824, ECO:0000269\|PubMed:15537631, ECO:0000269\|PubMed:19806195, ECO:0000269\|PubMed:20693240, ECO:0000269\|PubMed:30250067}.