3.0
Summary
| Name |  KLHL3View Modifications |
| Full Name | Kelch-like protein 3 |
| Synonyms | KLHL3_HUMAN | KIAA1129 |
| Primary ID | Q9UH77 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PKA | up-regulates activity 
phosphorylation
|
KLHL3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PKC | up-regulates quantity by stabilization
phosphorylation
|
KLHL3 | 0.2 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | AKT | up-regulates activity
phosphorylation
|
KLHL3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | KLHL3 | down-regulates quantity by destabilization 
binding
|
WNK4 | 0.612 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KLHL3 | up-regulates activity
binding
|
Cullin 3-RBX1-Skp1 | 0.64 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | KLHL3 | down-regulates quantity by destabilization
binding
|
WNK1 | 0.588 |
| Publications: | 1 | Organism: | Homo Sapiens | |