Summary

Name KLF15
Full Name Krueppel-like factor 15
Synonyms Kidney-enriched krueppel-like factor | KKLF
Primary ID Q9UIH9
Links - -
Type protein
Relations 6
Function Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.

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Relations

Regulator Mechanism target score ℹ
+ NR3C1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF15 0.389
Publications: 1 Organism: Mus Musculus
+ KLF15up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.454
Publications: 1 Organism: Mus Musculus
+ KLF15up-regulates img/indirect-activation.png transcriptional regulation Adipogenesis 0.7
Publications: 1 Organism: Mus Musculus
+ KLF15down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RHO 0.278
Publications: 1 Organism: Homo Sapiens
+ IL17Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KLF15 0.2
Publications: 1 Organism: Homo Sapiens
+ KLF15down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RBP3 0.27
Publications: 1 Organism: Homo Sapiens