| + |
GDF2 | up-regulates 
binding
|
ACVRL1 |
0.904 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17068149 |
Finally, we demonstrate that bmp9 and bmp10 potently inhibit endothelial cell migration and growth, and stimulate endothelial expression of a panel of genes that was previously reported to be activated by the constitutively active form of alk1. Taken together, our results suggest that bmp9 and bmp10 are two specific alk1 ligands that may physiologically trigger the effects of alk1 on angiogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ENG | up-regulates activity
binding
|
GDF2 |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276656 |
|
|
Homo sapiens |
A-204 Cell |
| pmid |
sentence |
| 21737454 |
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. We found that mouse and human endoglin ECD-Fc bound directly, specifically, and with high affinity to bone morphogenetic proteins 9 and 10 (BMP9 and BMP10) in surface plasmon resonance (Biacore) and cell-based assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GDF2 | up-regulates 
|
ALPL |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19175684 |
Wnt3a and bmp-9 enhanced each other's ability to induce alp in mscs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GDF2
- 
- 