| + |
ALPL | down-regulates activity 
dephosphorylation
|
SPP1 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277045 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23427088 |
This result suggests that endogenous mouse TNAP dephosphorylates OPN in osteoblasts and that overexpressed human TNAP dephosphorylates OPN, compensating for the lack of endogenous TNAP in [Col1a1-Tnap +/\u2212 ;Alpl \u2212/\u2212 ] cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FGF2 | down-regulates quantity by repression 
transcriptional regulation
|
ALPL |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252194 |
|
|
Homo sapiens |
MC3T3-E1(C4) Cell |
| pmid |
sentence |
| 19049325 |
FGF2 increases PC-1 and Ank expression while inhibiting Tnap expression in primary pre-osteoblast cells. Additionally, we show that the induction of PC-1 by FGF2 is cell type specific and mediated by the transcription factor, Runx2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALPL | down-regulates activity
dephosphorylation
|
MAPT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277097 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24646911 |
TNAP dephosphorylates overphosphorylated tau once it is released upon neuronal death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GDF2 | up-regulates 
|
ALPL |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19175684 |
Wnt3a and bmp-9 enhanced each other's ability to induce alp in mscs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT3A | up-regulates
|
ALPL |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19175684 |
Wnt3a and bmp-9 enhanced each other's ability to induce alp in mscs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX2 | up-regulates quantity by expression
transcriptional regulation
|
ALPL |
0.474 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331591 |
In addition to osteocalcin, cbfa1 regulates expression of several other genes that are activated during osteoblast |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALPL | up-regulates
|
Bone_mineralization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19049325 |
PC-1 and Tnap work together to produce normally mineralized bone matrix through the generation and hydrolysis of pyrophosphate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP2 | up-regulates
|
ALPL |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114589 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
FGF-2 null mice have impaired nuclear accumulation of Runx2 and hindered BMP-2 induced bone formation and ALP activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ALPL
- 
- 