Summary

Name ALPL
Full Name Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms AP-TNAP, TNSALP, Alkaline phosphatase liver/bone/kidney isozyme
Primary ID P05186
Links - -
Type protein
Relations 6
Function This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi).

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Relations

Regulator Mechanism target score ℹ
+ ALPLup-regulates img/indirect-activation.png Bone_mineralization 0.7
Publications: 1 Organism: Homo Sapiens
+ FGF2down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ALPL 0.389
Publications: 1 Organism: Homo Sapiens
+ GDF2up-regulates img/indirect-activation.png ALPL 0.26
Publications: 1 Organism: Homo Sapiens
+ RUNX2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALPL 0.481
Publications: 1 Organism: Homo Sapiens
+ BMP2up-regulates img/indirect-activation.png ALPL 0.455
Publications: 1 Organism: Homo Sapiens
+ WNT3Aup-regulates img/indirect-activation.png ALPL 0.351
Publications: 1 Organism: Homo Sapiens