Summary

Name FBXW11
Full Name F-box/WD repeat-containing protein 11
Synonyms F-box and WD repeats protein beta-TrCP2, F-box/WD repeat-containing protein 1B, Homologous to Slimb protein, HOS | BTRCP2, FBW1B, FBXW1B, KIAA0696
Primary ID Q9UKB1
Links - -
Type protein
Relations 13
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png ubiquitination NFKBIA 0.30
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination SMAD3 0.21
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination SMAD4 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CLSPN 0.68
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SKP1 0.93
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CTNNB1
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination EEF2K 0.77
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SUFU 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination PER1 0.50
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney