| + |
FBXW11 | down-regulates 
ubiquitination
|
NFKBIA |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26573 |
Lys21 |
EGPRDGLkKERLLDD |
Homo sapiens |
|
| pmid |
sentence |
| 7479976 |
Here we provide evidence that lysine residues 21 and 22 serve as the primary sites for signal-induced ubiquitination of i kappa b alpha. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64317 |
Lys21 |
EGPRDGLkKERLLDD |
Homo sapiens |
|
| pmid |
sentence |
| 9990853 |
We report here the identification of an ikappab-ubiquitin (ub) ligase complex containing the f-box/wd40-repeat protein, beta-trcp, a vertebrate homolog of drosophila slimb. beta-trcp binds to ikappabalpha only when the latter is specifically phosphorylated by an ikappab kinase complex. here we provide evidence that lysine residues 21 and 22 serve as the primary sites for signal-induced ubiquitination of i kappa b alpha. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26577 |
Lys22 |
GPRDGLKkERLLDDR |
Homo sapiens |
|
| pmid |
sentence |
| 7479976 |
Here we provide evidence that lysine residues 21 and 22 serve as the primary sites for signal-induced ubiquitination of i kappa b alpha. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64321 |
Lys22 |
GPRDGLKkERLLDDR |
Homo sapiens |
|
| pmid |
sentence |
| 9990853 |
We report here the identification of an ikappab-ubiquitin (ub) ligase complex containing the f-box/wd40-repeat protein, beta-trcp, a vertebrate homolog of drosophila slimb. beta-trcp binds to ikappabalpha only when the latter is specifically phosphorylated by an ikappab kinase complex. here we provide evidence that lysine residues 21 and 22 serve as the primary sites for signal-induced ubiquitination of i kappa b alpha. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
UBE2E3 | up-regulates quantity by stabilization 
sumoylation
|
NFKBIA |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270545 |
Lys21 |
EGPRDGLkKERLLDD |
Homo sapiens |
HEK-293 Cell, HeLa Cell |
| pmid |
sentence |
| 10582246 |
In the presence of an E1 SUMO-1-activating enzyme, Ubch9 conjugated SUMO-1 to IkappaBalpha primarily on K21, which is also utilized for ubiquitin modification. Thus, SUMO-1-modified IkappaBalpha cannot be ubiquitinated and is resistant to proteasome-mediated degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | down-regulates
phosphorylation
|
NFKBIA |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40502 |
Ser283 |
NLQMLPEsEDEESYD |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8622692 |
Casein kinase ii phosphorylates i kappa b alpha at s-283, s-289, s-293, and t-291 and is required for its degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40506 |
Ser288 |
PESEDEEsYDTESEF |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8622692 |
Casein kinase ii phosphorylates i kappa b alpha at s-283, s-289, s-293, and t-291 and is required for its degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40510 |
Ser293 |
EESYDTEsEFTEFTE |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8622692 |
Casein kinase ii phosphorylates i kappa b alpha at s-283, s-289, s-293, and t-291 and is required for its degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40514 |
Thr291 |
EDEESYDtESEFTEF |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8622692 |
Casein kinase ii phosphorylates i kappa b alpha at s-283, s-289, s-293, and t-291 and is required for its degradation. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES |
| + |
RPS6KA2 | down-regulates
phosphorylation
|
NFKBIA |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164790 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
|
| pmid |
sentence |
| 20385620 |
Rsk2 is activated by treatment with tumor necrosis factor-alfa (tnf-alfa) and directly phosphorylates ikbalfa at ser-32, leading to ikbalfa degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKK-complex | down-regulates
phosphorylation
|
NFKBIA |
0.887 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216385 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
|
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216389 |
Ser36 |
RHDSGLDsMKDEEYE |
Homo sapiens |
|
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21232017 |
Tak1 become activated and then phosphorilates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling, T cell activation, Toll like receptors |
| + |
AURKC | up-regulates activity
phosphorylation
|
NFKBIA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278470 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
|
| pmid |
sentence |
| 29050234 |
AURKC directly induces IkappaBalpha activation via an interaction between the two proteins, leading to phosphorylation of IkappaBalpha.|AURKC phosphorylates IkappaBalpha on S32 and binds its ankyrin repeat domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2AK2 | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249335 |
Ser32 |
LLDDRHDsGLDSMKD |
|
|
| pmid |
sentence |
| 10723127 |
As described for other stimuli, following pIC treatment, PKR phosphorylates the NF-kappa B inhibitor I kappa B alpha at serine 32 before degradation. |
|
| Publications: |
1 |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES |
| + |
CHUK | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.895 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52875 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52879 |
Ser36 |
RHDSGLDsMKDEEYE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IKBKG | down-regulates activity
phosphorylation
|
NFKBIA |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280462 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
PBMC Cell Line |
| pmid |
sentence |
| 18412279 |
IκB components are phosphorylated on two amino-terminal serine residues by the IκB kinase (IKK) complex, composed of two catalytic proteins, IKKα and IKKβ, and the regulatory subunit IKKγ (NEMO, IKBKG). This modification targets IκB for degradation by the proteasome, allowing the release and nuclear translocation of NF-κB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors |
| + |
IKBKB | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249365 |
Ser32 |
LLDDRHDsGLDSMKD |
|
|
| pmid |
sentence |
| 11815618 |
Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkapapB. The phosphorylation of I_Balpha on Ser32 and Ser36 is initiated by an IkapapB kinase (IKK) complex that includes a catalytic heterodimer composed of I_B kinase 1 (IKK-1) and IkapapB kinase 2 (IKK-2) as well as a regulatory adaptor subunit, NF-kappaB essential modulator. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249366 |
Ser36 |
RHDSGLDsMKDEEYE |
|
|
| pmid |
sentence |
| 11815618 |
Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkapapB. The phosphorylation of I_Balpha on Ser32 and Ser36 is initiated by an IkapapB kinase (IKK) complex that includes a catalytic heterodimer composed of I_B kinase 1 (IKK-1) and IkapapB kinase 2 (IKK-2) as well as a regulatory adaptor subunit, NF-kappaB essential modulator. |
|
| Publications: |
2 |
| Pathways: | FLT3-ITD signaling |
| + |
RPS6KA1 | up-regulates activity
phosphorylation
|
NFKBIA |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279311 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
|
| pmid |
sentence |
| 10398585 |
Mitogen activated ribosomal S6 kinase (p90 rsk1) phosphorylates IkappaBalpha at S32, binds IkappaBalpha in vivo, and overexpression of dominant negative p90 rsk1 inhibits degradation of IkappaBalpha in response to TPA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Inhibition of Apoptosis |
| + |
CSNK2A1 | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249332 |
Ser32 |
LLDDRHDsGLDSMKD |
|
|
| pmid |
sentence |
| 10398585 |
Serine 32 and serine 36 of IkappaBalpha are directly phosphorylated by protein kinase CKII in vitro|Phosphorylation of IkappaBalpha at serine 32 (S32) and serine 36 (S36) is necessary for this stimuli-induced degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249333 |
Ser36 |
RHDSGLDsMKDEEYE |
|
|
| pmid |
sentence |
| 10398585 |
Serine 32 and serine 36 of IkappaBalpha are directly phosphorylated by protein kinase CKII in vitro|Phosphorylation of IkappaBalpha at serine 32 (S32) and serine 36 (S36) is necessary for this stimuli-induced degradation |
|
| Publications: |
2 |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES |
| + |
AURKA | down-regulates activity
phosphorylation
|
NFKBIA |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278912 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
|
| pmid |
sentence |
| 23993973 |
The results of the in vitro kinase assay, using purified human recombinant AURKA and IkappaBalpha proteins, confirmed that AURKA can directly phosphorylate IkappaBalpha (Ser32) at a concentration as low as 2.5 ng/mul (XREF_FIG).|While an earlier study suggested that AURKA down-regulates IkappaBalpha indirectly through activation of the PI3K and AKT pathway 35, our data demonstrate, for the first time, that AURKA directly binds and phosphorylates the IkappaBalpha subunit, leading to activation of NF-kappaB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA3 | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279108 |
Ser32 |
LLDDRHDsGLDSMKD |
Homo sapiens |
|
| pmid |
sentence |
| 20385620 |
Here, we show that RSK2 is activated by treatment with tumor necrosis factor-alpha (TNF-alpha) and directly phosphorylates IkappaBalpha at Ser 32, leading to IkappaBalpha degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKK-complex | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.887 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209773 |
Ser36 |
RHDSGLDsMKDEEYE |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling, T cell activation, Toll like receptors |
| + |
IKBKE | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.486 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249367 |
Ser36 |
RHDSGLDsMKDEEYE |
|
|
| pmid |
sentence |
| 11815618 |
Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkapapB. |TBK-1 and IKK-i phosphorylate Ser36 of IkappaBalpha. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167524 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20717897 |
The activated ikk complex then phosphorylates ikbalfa (an inhibitor of nf-kb) thereby targeting it for ubiquitination and proteasomal degradation. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Toll like receptors |
| + |
TBK1 | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246643 |
Ser36 |
RHDSGLDsMKDEEYE |
Homo sapiens |
|
| pmid |
sentence |
| 11815618 |
Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkapapB. TBK-1 and IKK-i phosphorylate Ser36 of IkappaBalpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, Toll like receptors |
| + |
SRC | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.687 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60879 |
Tyr42 |
DSMKDEEyEQMVKEL |
Homo sapiens |
|
| pmid |
sentence |
| 9792645 |
C-src phosphorylates IkappaB On tyrosine 42|NF-kappaB is sequestered in the cytosol by IkappaBalpha and, in most cells, released upon serine phosphorylation of this inhibitory protein which then undergoes rapid, ubiquitin-dependent degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN1 | down-regulates
dephosphorylation
|
NFKBIA |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45004 |
Tyr42 |
DSMKDEEyEQMVKEL |
Homo sapiens |
|
| pmid |
sentence |
| 8940099 |
Ptp1b is able to dephosphorylate phosphorylated-tyr-42 on ikappabalpha |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LCK | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249374 |
Tyr42 |
DSMKDEEyEQMVKEL |
|
|
| pmid |
sentence |
| 14534291 |
Loss of tyrosine kinase p56lck in Jurkat cells abolished NFkappaB activation and partially suppressed and delayed phosphorylation of Tyr-42 of IkappaB upon pervanadate treatment. |Transfection of these cells with wild type Lck but not with mutant Lck F394 followed by H/R induces the tyrosine phosphorylation of inhibitor of nuclear factor kappaB (IkappaBalpha) and transcriptional activation of NFkappaB, and these are inhibited by Lck inhibitors |
|
| Publications: |
1 |
| Pathways: | T cell activation |
| + |
PTPN13 | up-regulates quantity by stabilization
dephosphorylation
|
NFKBIA |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248712 |
Tyr42 |
DSMKDEEyEQMVKEL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11106428 |
Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1|A full-length FAP-1 protein preferentially dephosphorylates Tyr-42 of IkBa|Moreover, other studies have shown that tyrosine phosphorylation of IkBa on Tyr-42 (which occurs with Fas ligand binging) protected against inducible degradation both in vitro [30] and in vivo [38] |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKBIA | up-regulates activity
binding
|
RELA |
0.889 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-17691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1340770 |
Nf-kappa b is an inducible transcription factor comprised of a 50-kd (p50) and a 65-kd (p65) subunit. Induction of nf-kappa b activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, i kappa b, followed by translocation of the active transcription factor complex into the nucleus. we demonstrate by in vitro and in vivo methods that the recently cloned i kappa b/mad-3 interacts with both the p50 and p65 subunits of nf-kappa b. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
G3BP2 | down-regulates activity
relocalization
|
NFKBIA |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260985 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10969074 |
IkappaBalpha interacts with G3BP2 both in vivo and in vitrothrough the IkappaBalpha CRS. Overexpression of G3BP2 directly promotes retention of IkappaBalpha in the cytoplasm. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES |
| + |
PCSK7 | down-regulates 
|
NFKBIA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235837 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 14767066 |
The levels of ikb_? Where reduced in cells overexpressing mkk6 [] these results indicated that mkk6 was able to promote the degradation of the NF-kappaB inhibitor, in a p38-dependent manner. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
TNFRSF1A | down-regulates quantity by destabilization
|
NFKBIA |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235789 |
|
|
Mus musculus |
MEF Cell, Macrophage |
| pmid |
sentence |
| 21232017 |
Tnfr1-induced phosforylation and degradarionn of ikb are almost completely abolished in tradd-deficient mefs,these hallmarks of classical nf-kn signaling are only attenuated in tradd-deficient macrophage. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network, Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, TNF-alpha Signaling |
| + |
CASP3 | up-regulates quantity by stabilization
cleavage
|
NFKBIA |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51936 |
|
|
in vitro |
|
| pmid |
sentence |
| 9367996 |
The cell-death protease cpp32 (caspase-3) in vitro specifically cleaved chicken and human ikappab-alpha at a conserved asp-ser sequence.Therefore, cleavage of I_B-_ by a CPP32-like protease could create what is sometimes called a super-repressor form of I_B-_ (20). That is, cleavage by CPP32 would block the ability of I_B-_ to undergo signal-induced degradation by removing the sites of signal-induced ubiquitination and by likely disrupting the ability of I_B-_ to become phosphorylated at critical Ser residues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, Inhibition of Apoptosis, TNF-alpha Signaling |
| + |
NFKBIA | down-regulates activity
binding
|
NfKb-p65/p50 |
0.812 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1340770 |
Nf-kappa b is an inducible transcription factor comprised of a 50-kd (p50) and a 65-kd (p65) subunit. Induction of nf-kappa b activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, i kappa b, followed by translocation of the active transcription factor complex into the nucleus. we demonstrate by in vitro and in vivo methods that the recently cloned i kappa b/mad-3 interacts with both the p50 and p65 subunits of nf-kappa b |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64092 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9914500 |
In nonstimulated cells, nf-kappab is present in the cytosol where it is complexed to its inhibitor ikappab however, we found that only one of the activities, namely the ikk1/2 complex, exists as a pre-assembled kinase-substrate complex in which the ikks are directly or indirectly associated with several nf-kappab-related and ikappab-related proteins: rela, relb, crel, p100, p105, ikappa balpha, ikappa bbeta and ikappa bepsilon. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV STRESS GRANULES, TNF-alpha Signaling, T cell activation, Toll like receptors |
| + |
ANXA3 | up-regulates activity 
|
NFKBIA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262213 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 27995049 |
We also investigated the potential regulation of cancer-associated signaling pathways by Anxa3 through screening for the altered expression of some common signaling molecules after Anxa3 downregulation. Decreased phosphorylation of MEK1/2, ERK1/2, Akt, and IκBα was detected after downregulating Anxa3 expression in A549 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKBIA | down-regulates quantity by repression
transcriptional regulation
|
S100A6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254804 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 12859951 |
Transient expression of NF-kappaB (p65) increased S100A6 promoter activity and expression of inhibitor of NF-kappaB (IkappaBalpha) decreased TNFalpha-induced S100A6 promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF7 | down-regulates activity
ubiquitination
|
NFKBIA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23136067 |
SAG (Sensitive to Apoptosis Gene), also known as RBX2 (RING box protein 2), ROC2 (Regulator of Cullins 2), or RNF7 (RING Finger Protein 7), was originally cloned in our laboratory as a redox inducible antioxidant protein and later characterized as the second member of the RBX/ROC RING component of the SCF (SKP1-CUL-F-box Proteins) E3 ubiquitin ligase. by forming a complex with other components of the SCF E3 ligase, SAG promotes ubiquitination and degradation of a number of protein substrates, including c-JUN, DEPTOR, HIF-1α, IκBα, NF1, NOXA, p27, and procaspase-3, thus regulating various signaling pathways and biological processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity by expression
transcriptional regulation
|
NFKBIA |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255688 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7569975 |
Here it is shown that the synthetic glucocorticoid dexamethasone induces the transcription of the IKBc gene, which results in an increased rate of IKBa protein synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKBIA | down-regulates activity
binding
|
NFKB1 |
0.735 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-17688 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1340770 |
Nf-kappa b is an inducible transcription factor comprised of a 50-kd (p50) and a 65-kd (p65) subunit. Induction of nf-kappa b activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, i kappa b, followed by translocation of the active transcription factor complex into the nucleus. we demonstrate by in vitro and in vivo methods that the recently cloned i kappa b/mad-3 interacts with both the p50 and p65 subunits of nf-kappa b |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BPLF1 | down-regulates activity
deubiquitination
|
NFKBIA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24586164 |
In the current study, we have found that BPLF1 interferes with innate immune activation by targeting multiple intermediates along the TLR signal transduction pathway, including TRAF6, NEMO, and IκBα. BPLF1 can remove ubiquitin tags from proteins in the TLR signaling cascade. This inhibits TLR signaling and decreases the expression of immune response genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection |
| + |
MAP3K7 | down-regulates quantity by destabilization
|
NFKBIA |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55716 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9480845 |
Overexpression of tak1 together with its activator protein, tak1 binding protein 1 (tab1), induced the nuclear translocation of nf-kappa b p50/p65 heterodimer accompanied by the degradation of i kappa b alpha and i kappa b beta, and the expression of kappa b-dependent reporter gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors |
| + |
Caspase 3 complex | up-regulates quantity by stabilization
cleavage
|
NFKBIA |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256456 |
|
|
in vitro |
|
| pmid |
sentence |
| 9367996 |
The cell-death protease cpp32 (caspase-3) in vitro specifically cleaved chicken and human ikappab-alpha at a conserved asp-ser sequence.Therefore, cleavage of I_B-_ by a CPP32-like protease could create what is sometimes called a super-repressor form of I_B-_ (20). That is, cleavage by CPP32 would block the ability of I_B-_ to undergo signal-induced degradation by removing the sites of signal-induced ubiquitination and by likely disrupting the ability of I_B-_ to become phosphorylated at critical Ser residues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ZBTB20 | down-regulates quantity by repression
transcriptional regulation
|
NFKBIA |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266868 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23776228 |
ChIP and next generation high-throughput DNA sequencing assay showed that ZBTB20 specifically bound to IκBα gene promoter (+1 to +60 region) after TLR activation. ZBTB20 could inhibit IκBα gene transcription, govern IκBα protein expression, and then promote NF-κB activation. Therefore, transcriptional repressor ZBTB20 is needed to promote full activation of TLR signaling and TLR-triggered innate immune response by selectively suppressing the suppressor IκBα gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKB | down-regulates activity
phosphorylation
|
NFKBIA |
0.921 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235400 |
|
|
Mus musculus |
MEF Cell, Macrophage |
| pmid |
sentence |
| 21232017 |
Tak1 become activated and then phosphorilates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | FLT3-ITD signaling |
4.0
NFKBIA
- 
- 