Summary

Name NFKBIA
Full Name NF-kappa-B inhibitor alpha
Synonyms I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major histocompatibility complex enhancer-binding protein MAD3 | IKBA, MAD3, NFKBI
Primary ID P25963
Links - -
Type protein
Relations 45
Pathways COVID-19 Causal Network, EBV infection, FAP: Glucocorticoids, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Macrophage: IL1 beta, Macrophage: TNF alpha, Mitochondrial dynamics in T cell exhaustion, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), Satellite: IL1 , SARS-CoV STRESS GRANULES, Satellite: TNFA, TNF-alpha Signaling, T cell activation, Toll like receptors, Tnfa_Notch_crosstalk
Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png sumoylation NFKBIA 0.353
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination NFKBIA 0.526
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFKBIA 0.569
Publications: 4 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.92
Publications: 2
Pathways:FLT3-ITD signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.518
Publications: 1
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ down-regulates img/direct_inhibition.png phosphorylation NFKBIA 0.269
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.894
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFKBIA 0.886
Publications: 3 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling, T cell activation, Toll like receptors
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.569
Publications: 2
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.467
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, Toll like receptors
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.496
Publications: 2 Organism: , Homo Sapiens
Pathways:COVID-19 Causal Network, Toll like receptors
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.886
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), TNF-alpha Signaling, T cell activation, Toll like receptors
+ down-regulates img/direct_inhibition.png dephosphorylation NFKBIA 0.361
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.57
Publications: 1
Pathways:T cell activation
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKBIA 0.675
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation NFKBIA 0.452
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png cleavage NFKBIA 0.43
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png relocalization NFKBIA 0.35
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ down-regulates img/indirect_inhibition.png NFKBIA 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by stabilization img/direct-activation.png cleavage NFKBIA 0.43
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png binding RELA 0.889
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding NfKb-p65/p50 0.811
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, FLT3-ITD signaling, IL1 Signaling , Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, Pancreatic ductal adenocarcinoma (PDA), SARS-CoV STRESS GRANULES, TNF-alpha Signaling, T cell activation, Toll like receptors
+ down-regulates activity img/direct_inhibition.png ubiquitination NFKBIA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png NFKBIA 0.537
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, TNF-alpha Signaling
+ down-regulates activity img/direct_inhibition.png binding NFKB1 0.734
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NFKBIA 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png NFKBIA 0.658
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation S100A6 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKBIA 0.33
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deubiquitination NFKBIA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ down-regulates activity img/direct_inhibition.png phosphorylation NFKBIA 0.92
Publications: 1 Organism: Mus Musculus
Pathways:FLT3-ITD signaling
+ up-regulates activity img/indirect-activation.png NFKBIA 0.2
Publications: 1 Organism: Homo Sapiens