Summary

Name CASP8AP2
Full Name CASP8-associated protein 2
Synonyms FLICE-associated huge protein | FLASH, KIAA1315, RIP25
Primary ID Q9UKL3
Links - -
Type protein
Relations 3
Function Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding NfKb-p65/p50 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NFKB1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CASP8AP2 0.28
Publications: 1 Organism: Homo Sapiens