3.0
Summary
| Name |  CASP8AP2
|
| Full Name | CASP8-associated protein 2 |
| Synonyms | FLICE-associated huge protein | FLASH, KIAA1315, RIP25 |
| Primary ID | Q9UKL3 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
binding