| + |
ZMYND8 | down-regulates quantity by repression 
transcriptional regulation
|
VEGFA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262041 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 27477906 |
Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | down-regulates quantity by repression
transcriptional regulation
|
MMP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262042 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 27477906 |
Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | down-regulates quantity by repression
transcriptional regulation
|
EGFR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262040 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 27477906 |
Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262038 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27477906 |
Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | down-regulates quantity by repression
transcriptional regulation
|
CD44 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262039 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 27477906 |
Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | up-regulates activity 
binding
|
ZMYND8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262037 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 27477906 |
We identified ZMYND8 as a transcriptional corepressor of the H3K4 demethylase JARID1D|Co-immunoprecipitation between ectopically expressed FLAG-tagged JARID1D and endogenous ZMYND8 protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | down-regulates quantity by repression
transcriptional regulation
|
MMP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262043 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 27477906 |
Our quantitative ChIP experiments confirmed that ZMYND8 and JARID1D were co-localized at Slug, CD44, VEGFA, and EGFR genes (Figures 4F–4I). Our ChIP results also showed that ZMYND8 repressed and occupied other JARID1D target genes, such as the matrix metalloproteinase 1 (MMP1) and MMP3, that we previously reported |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | up-regulates quantity by expression
transcriptional regulation
|
NAV2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266209 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21620140 |
We also confirmed transcriptional coactivator functions of ZMYND8 in ERα-driven reporter assays and on endogenous E2-dependent genes (Figure 5F,G). siRNA knockdown of ZMYND8 showed markedly decreased transcription at the presumptive ERα/Z3 target genes ADORA1 and NAV2, while the classical ERα targets pS2/TFF1 and GREB1 appear to be less affected (Figure 5G), suggesting likely gene-specificity of ZMYND8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRD2 | up-regulates activity
relocalization
|
ZMYND8 |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262036 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29018219 |
ZMYND8 and BRD2 therefore work together to protect H4Ac domains from HDAC activity.|Further, when BRD2 was depleted, ZMYND8 accumulation was lost (Fig. 2e), indicating that either BRD2, or the underlying H4Ac, is required for ZMYND8 loading. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYND8 | up-regulates quantity by expression
transcriptional regulation
|
ADORA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266208 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21620140 |
We also confirmed transcriptional coactivator functions of ZMYND8 in ERα-driven reporter assays and on endogenous E2-dependent genes (Figure 5F,G). siRNA knockdown of ZMYND8 showed markedly decreased transcription at the presumptive ERα/Z3 target genes ADORA1 and NAV2, while the classical ERα targets pS2/TFF1 and GREB1 appear to be less affected (Figure 5G), suggesting likely gene-specificity of ZMYND8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZMYND8
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