Relation Results

Summary

Name DAPP1
Full Name Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Synonyms hDAPP1, B lymphocyte adapter protein Bam32, B-cell adapter molecule of 32 kDa | BAM32
Primary ID Q9UN19
Links - -
Type protein
Relations 5
Function May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

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Type: Score: Layout: SPV 
0.570.610.6590.632SRCDAPP1LYNBTKLCK

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SRCup-regulates activity img/direct-activation.png phosphorylation DAPP1 0.57
Identifier Residue Sequence Organism Cell Line
SIGNOR-247119 Tyr139 KVEEPSIyESVRVHT Homo sapiens B-lymphocyte
pmid sentence
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell linesyrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins.
Publications: 1 Organism: Homo Sapiens
+ LYNup-regulates activity img/direct-activation.png phosphorylation DAPP1 0.61
Identifier Residue Sequence Organism Cell Line
SIGNOR-249378 Tyr139 KVEEPSIyESVRVHT B-lymphocyte
pmid sentence
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines|yrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins.
Publications: 1
+ BTKup-regulates activity img/direct-activation.png phosphorylation DAPP1 0.659
Identifier Residue Sequence Organism Cell Line
SIGNOR-249313 Tyr139 KVEEPSIyESVRVHT B-lymphocyte
pmid sentence
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines|yrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250602 Tyr139 KVEEPSIyESVRVHT in vitro
pmid sentence
We present a number of lines of evidence that in vivo, Src-type tyrosine kinases are responsible for the phosphorylation of tyrosine 139 in DAPP-1. | Although Btk appears to phosphorylate DAPP-1 relatively efficiently both in Sf9 cells and in vitro, we find no evidence that in either B cells or PAE cells Btk family kinases phosphorylate DAPP-1.
Publications: 2 Organism: , In Vitro
+ LCKup-regulates activity img/direct-activation.png phosphorylation DAPP1 0.632
Identifier Residue Sequence Organism Cell Line
SIGNOR-249373 Tyr139 KVEEPSIyESVRVHT
pmid sentence
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines|yrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins.
Publications: 1
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