Relation Results

Summary

Name G3BP2
Full Name Ras GTPase-activating protein-binding protein 2
Synonyms G3BP-2, GAP SH3 domain-binding protein 2 | KIAA0660
Primary ID Q9UN86
Links - -
Type protein
Relations 5
Pathways COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES
Function Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.

Viewer

Type: Score: Layout: SPV 
0.70.4610.3440.461G3BP2Stress_granulesG3BP1NFKBIA

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ G3BP2up-regulates img/indirect-activation.png Stress_granules 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-260983 Homo sapiens
pmid sentence
G3BP1 and G3BP2 form homo‐ and hetero‐multimers to induce SGs
Identifier Residue Sequence Organism Cell Line
SIGNOR-260864 Homo sapiens HEK-293 Cell
pmid sentence
Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a component of SGs that initiates the assembly of SGs by forming a multimer. In this study, we examined the role of G3BP2, a close relative of G3BP1, in SG formation. Although single knockdown of either G3BP1 or G3BP2 in 293T cells partially reduced the number of SG-positive cells induced by arsenite, the knockdowns of both genes significantly reduced the number. G3BP2 formed a homo-multimer and a hetero-multimer with G3BP1. Moreover, like G3BP1, the overexpression of G3BP2 induced SGs even without stress stimuli.
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES
+ G3BP2up-regulates activity img/direct-activation.png binding G3BP1 0.461
Identifier Residue Sequence Organism Cell Line
SIGNOR-260863 Homo sapiens HEK-293 Cell
pmid sentence
Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a component of SGs that initiates the assembly of SGs by forming a multimer. In this study, we examined the role of G3BP2, a close relative of G3BP1, in SG formation. Although single knockdown of either G3BP1 or G3BP2 in 293T cells partially reduced the number of SG-positive cells induced by arsenite, the knockdowns of both genes significantly reduced the number. G3BP2 formed a homo-multimer and a hetero-multimer with G3BP1. Moreover, like G3BP1, the overexpression of G3BP2 induced SGs even without stress stimuli.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES
+ G3BP2down-regulates activity img/direct_inhibition.png relocalization NFKBIA 0.344
Identifier Residue Sequence Organism Cell Line
SIGNOR-260985 Homo sapiens HeLa Cell
pmid sentence
IkappaBalpha interacts with G3BP2 both in vivo and in vitrothrough the IkappaBalpha CRS. Overexpression of G3BP2 directly promotes retention of IkappaBalpha in the cytoplasm.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ G3BP1up-regulates activity img/direct-activation.png binding G3BP2 0.461
Identifier Residue Sequence Organism Cell Line
SIGNOR-260862 Homo sapiens HEK-293 Cell
pmid sentence
Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a component of SGs that initiates the assembly of SGs by forming a multimer. In this study, we examined the role of G3BP2, a close relative of G3BP1, in SG formation. Although single knockdown of either G3BP1 or G3BP2 in 293T cells partially reduced the number of SG-positive cells induced by arsenite, the knockdowns of both genes significantly reduced the number. G3BP2 formed a homo-multimer and a hetero-multimer with G3BP1. Moreover, like G3BP1, the overexpression of G3BP2 induced SGs even without stress stimuli.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES
a simple tooltip