3.0
Summary
| Name |  AURKCView Modifications |
| Full Name | Aurora kinase C |
| Synonyms | Aurora 3, Aurora/IPL1-related kinase 3, ARK-3, Aurora-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C | AIE2, AIK3, AIRK3, ARK3, STK13 |
| Primary ID | Q9UQB9 |
| Links |  -  -  |
| Type | protein |
| Relations | 15 |
| Inhibitors | 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylurea; N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide; AMG 900; N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide; ZM447439; CCT129202; CCT137690; PHA-680632; SNS-314 Mesylate |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AURKC | up-regulates activity 
phosphorylation
|
H3C1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | AURKC | up-regulates activity
phosphorylation
|
TACC1 | 0.41 |
| Publications: | 1 | Organism: | In Vitro | |
| + | 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylurea | down-regulates activity 
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide | down-regulates activity
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | AMG 900 | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZM447439 | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AURKC | up-regulates
phosphorylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CCT129202 | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CCT137690 | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHA-680632 | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylurea | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SNS-314 Mesylate | down-regulates
chemical inhibition
|
AURKC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |