| + |
TRIM27 | up-regulates activity 
ubiquitination
|
STK38L |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270347 |
Lys119 |
TGHIYAMkILRKSDM |
Mus musculus |
|
| pmid |
sentence |
| 35670107 |
TRIM27 catalyzes non-degradative K6- and K11-linked ubiquitination of the serine/threonine kinase 38-like (STK38L) kinase. In turn, STK38L ubiquitination promotes its activation and phosphorylation of ULK1 at Ser495, rendering ULK1 in a permissive state for TRIM27-mediated hyper-ubiquitination of ULK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270346 |
Lys73 |
RRSQHARkETEFLRL |
Mus musculus |
|
| pmid |
sentence |
| 35670107 |
TRIM27 catalyzes non-degradative K6- and K11-linked ubiquitination of the serine/threonine kinase 38-like (STK38L) kinase. In turn, STK38L ubiquitination promotes its activation and phosphorylation of ULK1 at Ser495, rendering ULK1 in a permissive state for TRIM27-mediated hyper-ubiquitination of ULK1 |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
STK38L | up-regulates
phosphorylation
|
STK38L |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142518 |
Ser282 |
NRRQLAYsTVGTPDY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16314523 |
Ndr1/ndr2 protein kinase is activated by phosphorylation on the activation loop phosphorylation site ser281/ser282 and the hydrophobic motif phosphorylation site thr444/thr442. Autophosphorylation of ndr is responsible for phosphorylation on ser281/ser282, whereas thr444/thr442 is targeted by an upstream kinase. Here we show that mst3, a mammalian ste20-like protein kinase, is able to phosphorylate ndr protein kinase at thr444/thr442. In vitro, mst3 selectively phosphorylated thr442 of ndr2, resulting in a 10-fold stimulation of ndr activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK38L | down-regulates quantity 
phosphorylation
|
ULK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270348 |
Ser495 |
GVLARKMsLGGGRPY |
Mus musculus |
|
| pmid |
sentence |
| 35670107 |
STK38L ubiquitination promotes its activation and phosphorylation of ULK1 at Ser495, rendering ULK1 in a permissive state for TRIM27-mediated hyper-ubiquitination |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STK24 | up-regulates
phosphorylation
|
STK38L |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142510 |
Thr442 |
DWVFLNYtYKRFEGL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16314523 |
Ndr1/ndr2 protein kinase is activated by phosphorylation on the activation loop phosphorylation site ser281/ser282 and the hydrophobic motif phosphorylation site thr444/thr442. Autophosphorylation of ndr is responsible for phosphorylation on ser281/ser282, whereas thr444/thr442 is targeted by an upstream kinase. Here we show that mst3, a mammalian ste20-like protein kinase, is able to phosphorylate ndr protein kinase at thr444/thr442. In vitro, mst3 selectively phosphorylated thr442 of ndr2, resulting in a 10-fold stimulation of ndr activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
STK38L
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