3.0
Summary
| Name |  STK24View Modifications |
| Full Name | Serine/threonine-protein kinase 24 |
| Synonyms | Mammalian STE20-like protein kinase 3, MST-3, STE20-like kinase MST3 | MST3, STK3 |
| Primary ID | Q9Y6E0 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA |
phosphorylation
|
STK24 | 0.219 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain, Kidney | |||
| + | STK24 | up-regulates 
phosphorylation
|
STK24 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Kidney | |||
| + | STK24 | up-regulates
phosphorylation
|
STK38L | 0.451 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STK24 | up-regulates
phosphorylation
|
STK38 | 0.39 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STK24 | up-regulates activity
phosphorylation
|
RAB8A | 0.279 |
| Publications: | 1 | Organism: | In Vitro | |