3.0
Summary
| Name |  STIM1View Modifications |
| Full Name | Stromal interaction molecule 1 |
| Synonyms | STIM1_HUMAN | GOK |
| Primary ID | Q13586 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKAA1 | down-regulates activity 
phosphorylation
|
STIM1 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PRKAG2 | down-regulates activity
phosphorylation
|
STIM1 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PRKAB1 | down-regulates activity
phosphorylation
|
STIM1 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | MAPK1 | up-regulates 
phosphorylation
|
STIM1 | 0.359 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | down-regulates
phosphorylation
|
STIM1 | 0.353 |
| Publications: | 1 | Organism: | Homo Sapiens | |