3.0
Summary
| Name |  ARFGEF1View Modifications |
| Full Name | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 |
| Synonyms | Brefeldin A-inhibited GEP 1, ADP-ribosylation factor guanine nucleotide-exchange factor 1, p200 ARF guanine nucleotide exchange factor, p200 ARF-GEP1 | ARFGEP1, BIG1 |
| Primary ID | Q9Y6D6 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates activity 
phosphorylation
|
ARFGEF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARFGEF1 | up-regulates activity
guanine nucleotide exchange factor
|
ARF1 | 0.584 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARFGEF1 | up-regulates activity
guanine nucleotide exchange factor
|
ARF3 | 0.374 |
| Publications: | 1 | Organism: | Homo Sapiens | |