| + |
JAK1 | form complex 
binding
|
JAK1/STAT1/STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235608 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15284024 |
Stimulation of EGFR induces Tyr701 phosphorylation of STAT1 and initiates complex formation of STAT1 and STAT3 with JAK1 and JAK2. Thereafter, the STATs translocate to the nucleus within 15 min. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EGFR | up-regulates activity 
phosphorylation
|
JAK1/STAT1/STAT3 |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252088 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15284024 |
Stimulation of EGFR induces Tyr701 phosphorylation of STAT1 and initiates complex formation of STAT1 and STAT3 with JAK1 and JAK2. Thereafter, the STATs translocate to the nucleus within 15 min. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA) |
| + |
STAT1/STAT3 | form complex
binding
|
JAK1/STAT1/STAT3 |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235658 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15284024 |
Stimulation of EGFR induces Tyr701 phosphorylation of STAT1 and initiates complex formation of STAT1 and STAT3 with JAK1 and JAK2. Thereafter, the STATs translocate to the nucleus within 15 min. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
JAK1/STAT1/STAT3 | up-regulates 
|
Fibrosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256231 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Taken together, our data show IL-15 can enhance the collagen deposition in vivo after muscle damage and this process can be prevented by blocking Jak-STAT pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1/STAT1/STAT3 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256230 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
In summary, our results indicate IL-15 can stimulate the proliferation of FAPs through Jak-STAT pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA) |
3.0
JAK1/STAT1/STAT3