| + |
Caspase 6 complex | down-regulates 
cleavage
|
LMNA |
0.664 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11058599 |
Lamin a breakdown is largely mediated by caspase-6 during the execution phase of apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP6 | form complex 
binding
|
Caspase 6 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256392 |
|
|
|
|
| pmid |
sentence |
| 21621544 |
It is generally recognized that effector caspases undergo proteolytic cleavage of the inactive zymogen at a specific aspartate residue, resulting in a large N-terminal p20 polypeptide chain and a small C-terminal p10 polypeptide chain, leading to a p202/p102 tetramer. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256391 |
|
|
|
|
| pmid |
sentence |
| 21621544 |
It is generally recognized that effector caspases undergo proteolytic cleavage of the inactive zymogen at a specific aspartate residue, resulting in a large N-terminal p20 polypeptide chain and a small C-terminal p10 polypeptide chain, leading to a p202/p102 tetramer. |
|
| Publications: |
2 |
| + |
Caspase 6 complex | up-regulates 
cleavage
|
CASP8 |
0.734 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11455969 |
This pathway can either be ampli?ed By caspase- 8-mediated cleavage of bid and by the downstream, caspase-6- mediated cleavage of caspase-8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Caspase 6 complex
CPX-971