Summary

Name CASP6
Full Name Caspase-6
Synonyms CASP-6, Apoptotic protease Mch-2 | MCH2
Primary ID P55212
Links - -
Type protein
Relations 16
Pathways COVID-19 Causal Network, SARS-COV APOPTOSIS
Function Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed:8663580, PubMed:32298652). During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:17401638, PubMed:8663580, PubMed:9463409). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (PubMed:10559921, PubMed:14657026). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses (PubMed:32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed:32298652).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CASP6up-regulates activity img/direct-activation.png cleavage PSEN2 0.37
Publications: 2 Organism: In Vitro
+ CASP6up-regulates activity img/direct-activation.png cleavage PSEN1 0.379
Publications: 2 Organism: In Vitro
+ CASP6up-regulates activity img/direct-activation.png cleavage N 0.2
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ CASP6up-regulates activity img/direct-activation.png cleavage APP 0.712
Publications: 1 Organism: In Vitro
+ NUAK1down-regulates activity img/direct_inhibition.png phosphorylation CASP6 0.497
Publications: 1 Organism: In Vitro
+ CASP6up-regulates img/direct-activation.png cleavage CASP8 0.722
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ CASP8up-regulates img/direct-activation.png cleavage CASP6 0.722
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ CASP6form complex img/form-complex.png binding Caspase 6 complex 0.2
Publications: 2
+ CASP3up-regulates img/direct-activation.png cleavage CASP6 0.601
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ Caspase 8 complexup-regulates img/direct-activation.png cleavage CASP6 0.722
Publications: 1 Organism: Homo Sapiens
+ CASP6down-regulates img/direct_inhibition.png cleavage LMNA 0.648
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates img/direct-activation.png cleavage CASP6 0.601
Publications: 1 Organism: Homo Sapiens