| + |
Apoptosome | up-regulates activity 
cleavage
|
CASP3 |
0.729 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15657060 |
Following autoprocessing in the apoptosome, caspase-9 cleaves and activates caspase-3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256472 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9390557 |
Activated caspase-9 in turn cleaves and activates caspase-3. Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer |
| + |
APAF1 | form complex 
binding
|
Apoptosome |
0.87 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256431 |
|
|
in vitro |
|
| pmid |
sentence |
| 10206961 |
APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively. The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex. Such a complex can be isolated using gel filtration chromatography and is by itself sufficient to recruit and activate procaspase-9. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Alzheimer |
| + |
CASP9 | form complex
binding
|
Apoptosome |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256429 |
|
|
in vitro |
|
| pmid |
sentence |
| 10206961 |
APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively. The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex. Such a complex can be isolated using gel filtration chromatography and is by itself sufficient to recruit and activate procaspase-9. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CYCS | form complex
binding
|
Apoptosome |
0.832 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256430 |
|
|
in vitro |
|
| pmid |
sentence |
| 10206961 |
APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively. The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex. Such a complex can be isolated using gel filtration chromatography and is by itself sufficient to recruit and activate procaspase-9. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Alzheimer |
3.0
Apoptosome
CPX-3762