Summary

Name APAF1
Full Name Apoptotic protease-activating factor 1
Synonyms APAF-1 | KIAA0413
Primary ID O14727
Links - -
Type protein
Relations 12
Pathways Death Receptor Signaling, Mitochondrial Control of Apoptosis, Alzheimer Disease
Function Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding APAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding APAF1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates img/direct-activation.png binding CASP9 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis
+ form complex img/form-complex.png binding Apoptosome 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding APAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding APAF1 0.48
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png binding APAF1 0.7
Publications: 4 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis
+ up-regulates activity img/direct-activation.png binding CASP9 0.42
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis