| + |
AKT3 | down-regulates activity 
phosphorylation
|
CYCS |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277235 |
Tyr47 |
KTGQAPGySYTAANK |
in vitro |
|
| pmid |
sentence |
| 32781572 |
Finally, we propose that pro-survival kinase Akt (protein kinase B) is a likely mediator of the S47 phosphorylation of Cytc in the brain. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AKT2 | down-regulates activity
phosphorylation
|
CYCS |
0.291 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277236 |
Tyr47 |
KTGQAPGySYTAANK |
in vitro |
|
| pmid |
sentence |
| 32781572 |
Finally, we propose that pro-survival kinase Akt (protein kinase B) is a likely mediator of the S47 phosphorylation of Cytc in the brain. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AKT1 | down-regulates activity
phosphorylation
|
CYCS |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277237 |
Tyr47 |
KTGQAPGySYTAANK |
in vitro |
|
| pmid |
sentence |
| 32781572 |
Finally, we propose that pro-survival kinase Akt (protein kinase B) is a likely mediator of the S47 phosphorylation of Cytc in the brain. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Parkinson |
| + |
GHITM | down-regulates quantity
relocalization
|
CYCS |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260294 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18417609 |
MICS1 was clearly coprecipitated with cytochrome c-3FLAG and the amount was DSP concentration-dependent (Figure 6A). Together with the finding that overexpression of exogenous MICS1 delayed the apoptotic release of cytochrome c in normal-serum level medium (Figure 4A), these results suggest that MICS1 helps to retain cytochrome c in the inner membrane, apart from the morphological changes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression 
transcriptional regulation
|
CYCS |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253097 |
|
|
Mus musculus |
Adipocyte |
| pmid |
sentence |
| 23021218 |
PGC1a is known to drive the expression of many genes involved in mitochondrial oxidative phosphorylation, including cytochrome c (CytC) and the cyto- chrome C oxidative (COX) subunits (CoxIII, Cox4il, Cox5b, Cox7a, and Cox8b). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BAX | up-regulates
|
CYCS |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160039 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18097445 |
This process of mitochondrial outer membrane permeabilization (momp) results in the release of cycs.it is commonly thought that bax and bak form pores in membranes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
CYCS | up-regulates activity 
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.763 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280292 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10563795 |
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four protons occurs after the binding of oxygen to the reduced enzyme and is exclusively coupled to the last two electron transfer steps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYCS | up-regulates activity
binding
|
APAF1 |
0.789 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137295 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15907471 |
Cytochrome c (Cyt c) is then released from the intermembrane space of the mitochondrion into the cytosol, where it binds to apoptotic protease-activating factor 1 (Apaf-1) in the presence of ATP/dATP to form the apoptosome. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16977332 |
Apaf-1 exists in an inactive conformation in cells and is activated through binding to cytochrome c and dATP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-50585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9267021 |
Once released from mitochondria, cytochrome c binds to Apaf-1, which may trigger the activation of caspase-3 in the presence of dATP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15829969 |
During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
TP53 | up-regulates
|
CYCS |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140251 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19007744 |
P53 translocation precedes changes of mitochondrial membrane potential, cytochrome c release and caspase activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Mitochondrial Control of Apoptosis |
| + |
CoQ-cytochrome c reductase-Mitochondrial respiratory chain complex III | up-regulates activity
chemical modification
|
CYCS |
0.848 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280290 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14977419 |
The bc1 complexes are intrinsic membrane proteins that catalyze the oxidation of ubihydroquinone and the reduction of cytochrome c in mitochondrial respiratory chains and bacterial photosynthetic and respiratory chains. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
heme b | up-regulates activity
chemical modification
|
CYCS |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280297 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23150584 |
Spectroscopic analyses of HCCS alone and complexes of HCCS with site-directed variants of cytochrome c revealed the fundamental steps of heme attachment and maturation. A conserved histidine in HCCS (His154) provided the key ligand to the heme iron. Formation of the HCCS:heme complex served as the platform for interaction with apocytochrome c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCL2 | down-regulates activity 
|
CYCS |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99063 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12624108 |
Bcl-2 blocked the release of mitochondrial cytochrome c |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
BAK1 | up-regulates
|
CYCS |
0.562 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18097445 |
This process of mitochondrial outer membrane permeabilization (momp) results in the release of cycs. It is commonly thought that bax and bak form pores in membranes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3a | up-regulates activity
|
CYCS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18632968 |
Thus, caspase-9 activation and cytochrome c release in cells expressing the 3a protein indicated that this viral protein also activates the intrinsic pathway of apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |
| + |
CYCS | form complex 
binding
|
Apoptosome |
0.834 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256430 |
|
|
in vitro |
|
| pmid |
sentence |
| 10206961 |
APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively. The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex. Such a complex can be isolated using gel filtration chromatography and is by itself sufficient to recruit and activate procaspase-9. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Alzheimer |
| + |
PRKAA1 | up-regulates quantity by expression
transcriptional regulation
|
CYCS |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156772 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17609368 |
Severalin vivostudies using aicar to activate ampk chronically determined that mitochondrial enzymes [e.g., cytochromec, uncoupling protein 3 (ucp-3)] (1518) and proteins involved in glucose uptake (glut4) (1820) are increased at the transcriptional level in skeletal muscle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
PINK1 | down-regulates quantity
|
CYCS |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249704 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20012177 |
There is a strong cyto-protective role of PINK1 in maintaining mitochondrial homeostasis via different mechanisms. Overexpression of wild-type PINK1 in SH-SY5Y neuroblastoma cells stabilizes respiring mitochondrial networks through various mechanisms that include maintaining mitochondrial membrane potential, reducing basal and neurotoxin-induced ROS, suppression of cytochrome c release, reversal of toxin-induced fission, and suppression of autophagy |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Parkinson |
| + |
BID | up-regulates activity
|
CYCS |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9727492 |
TBID induces first the clustering of mitochondria around the nuclei and release of cytochrome c. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
CYCS | up-regulates
|
Oxidative_phosphorylation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253100 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23021218 |
PGC1a is known to drive the expression of many genes involved in mitochondrial oxidative phosphorylation, including cytochrome c (CytC) and the cyto- chrome C oxidative (COX) subunits (CoxIII, Cox4il, Cox5b, Cox7a, and Cox8b). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CYCS | up-regulates activity
binding
|
CASP9 |
0.878 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53585 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9390557 |
Caspase-9 and apaf-1 bind to each other via their respective nh2-terminal ced-3 homologous domains in the presence of cytochrome c and datp, an event that leads to caspase-9 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, Parkinson, SARS-COV APOPTOSIS |
| + |
Caspase 8 complex | up-regulates activity
|
CYCS |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256473 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 10364179 |
Caspase-8 triggered rapid cytochrome c release from mitochondria. The effect was indirect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BAK1 | up-regulates
relocalization
|
CYCS |
0.562 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105206 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11175253 |
Allosteric activation of bak induces its intramembranous oligomerization into a proposed pore for cytochrome c efflux |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP8 | up-regulates activity
|
CYCS |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68225 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 10364179 |
Caspase-8 triggered rapid cytochrome c release from mitochondria. The effect was indirect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
| + |
HCCS | up-regulates activity
chemical modification
|
CYCS |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280296 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10563795 |
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four protons occurs after the binding of oxygen to the reduced enzyme and is exclusively coupled to the last two electron transfer steps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BAX | up-regulates
relocalization
|
CYCS |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73898 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10629050 |
The integration of bax oligomers in the outer mitochondrial membrane is followed by cytochrome crelease |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS |
4.0
CYCS
- 
- 