| + |
DNM1L | up-regulates 
|
Mitochondrial_fission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274132 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 17301055 |
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262553 |
|
|
Mus musculus |
Podocyte |
| pmid |
sentence |
| 31063459 |
Mitochondrial fission is governed primarily by the cytoplasmic dynamin-related protein 1 (Drp1). Drp1 is a conserved dynamin GTPase superfamily protein that is translocated from its cytoplasmic pool to the outer mitochondrial membrane, where Drp1 then assembles into constrictive ring-like multimeric structures, ultimately driving mitochondrial fragmentation through a GTP-dependent mechanism|We have also previously reported that ROCK1-mediated Drp1S600 phosphorylation resulted in enhanced mitochondrial fission in podocytes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272975 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25486875 |
During fission, DRP1 is recruited from the cytosol to the outer mitochondrial membrane, where it assembles with FIS1 to constrict the mitochondrial tubule (2) |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
MFF | up-regulates
|
Mitochondrial_fission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33610749 |
These proteins include the classical mitochondrial fusion (MFN1, MFN2, and OPA1) and fission proteins (DRP1, MFF, FIS1, etc.) as well as several other proteins that are directly or indirectly involved in these processes (e.g. YME1L, OMA1, INF2, GDAP1, MIC13, etc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OPA3 | up-regulates
|
Mitochondrial_fission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272988 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20372962 |
Optic atrophy 3 as a protein of the mitochondrial outer membrane induces mitochondrial fragmentation|Together, these results indicate that OPA3, as an integral MOM protein, has a crucial role in mitochondrial fission, and provides a direct link between mitochondrial morphology and optic atrophy. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GDAP1 | up-regulates
|
Mitochondrial_fission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272977 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33610749 |
However, it remains elusive if additional proteins are involved in the regulation of mitochondrial fission, such as proposed fission factor GDAP1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FIS1 | up-regulates
|
Mitochondrial_fission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272976 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25486875 |
During fission, DRP1 is recruited from the cytosol to the outer mitochondrial membrane, where it assembles with FIS1 to constrict the mitochondrial tubule (2) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Mitochondrial_fission