| + |
TLRs | up-regulates 
|
Interferon_Production |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216310 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20404851 |
TLR signaling pathways can be largely classified as either MyD88-dependent pathways, which drive the induction of inflammatory cytokines, or TRIF-dependent pathways, which are responsible for the induction of type I interferon as well as inflammatory cytokines3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Toll like receptors |
| + |
NfKb-p65/p50 | up-regulates
|
Interferon_Production |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216322 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 20610653 |
Type 1 IFNs are induced in a cell type-specific manner through Toll-like receptor and RIG-I-like receptor pathways, both of which activate interferon regulatory factors (IRFs) and nuclear factor _B (NF-_B) transcription factors. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | B-cell activation, EBV infection, Toll like receptors |
| + |
IRF3 | up-regulates
|
Interferon_Production |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126962 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 20610653 |
Type 1 IFNs are induced in a cell type-specific manner through Toll-like receptor and RIG-I-like receptor pathways, both of which activate interferon regulatory factors (IRFs) and nuclear factor _B (NF-_B) transcription factors. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | EBV infection, Toll like receptors |
| + |
TLR4 | up-regulates
|
Interferon_Production |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166488 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20596954 |
Regulation of toll-like receptor signaling in the innate immunity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Interferon_Production