| + |
NFIX | down-regulates quantity 
transcriptional regulation
|
GAS6 |
0.205 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268888 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GAS6 | up-regulates activity 
binding
|
AXL |
0.906 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277720 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 35022267 |
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. neutrophils are recruited to the metastatic liver via CXCL1 and 2 secretion by metastatic tumour cells. These neutrophils express growth arrest specific 6 (Gas6) which leads to AXL receptor activation on tumour cells enabling their regrowth.Taken together, these results show that the neutrophil attracting cytokines Cxcl1 and 2 are highly expressed in metastatic livers in response to gemcitabine withdrawal and this favours CXCR2-dependent recruitment of neutrophils at the hepatic metastatic site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GGCX | up-regulates activity
carboxylation
|
GAS6 |
0.505 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31226734 |
Thus, vitamin K acts as a cofactor for GGCX via the vitamin K cycle and exerts physiological effects through its regulation of VKDPs [29]. More than 20 VKDPs have been found. Osteocalcin promotes bone formation, and blood coagulation factors II, VII, IX, and X activate blood coagulation. Matrix Gla protein suppresses cardiovascular calcification, and brain-expressed Gas 6 promotes neural differentiation [29]. GGCX is an enzyme that converts glutamic acid (Glu) residues to Gla residues, so that the Gla-containing proteins can exert various physiological actions such as blood coagulation and bone formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Vitamin-K cycle |
| + |
GAS6 | up-regulates
binding
|
AXL |
0.906 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143109 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16362042 |
Receptor tyrosine kinases of the axl family are activated by the vitamin k-dependent protein gas6. We report the identification of ligands for tyro 3 (alternatively called sky, rse, brt, or tif) and axl (alternatively, ark or ufo), members of a previously orphan family of receptor-like tyrosine kinases. These ligands correspond to protein s, a protease regulator that is a potent anticoagulant, and gas6, a protein related to protein s but lacking any known function. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34339 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7867073 |
Receptor tyrosine kinases of the axl family are activated by the vitamin k-dependent protein gas6. We report the identification of ligands for tyro 3 (alternatively called sky, rse, brt, or tif) and axl (alternatively, ark or ufo), members of a previously orphan family of receptor-like tyrosine kinases. These ligands correspond to protein s, a protease regulator that is a potent anticoagulant, and gas6, a protein related to protein s but lacking any known function. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Neutrophil_activation | up-regulates 
|
GAS6 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277724 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 35022267 |
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. neutrophils are recruited to the metastatic liver via CXCL1 and 2 secretion by metastatic tumour cells. These neutrophils express growth arrest specific 6 (Gas6) which leads to AXL receptor activation on tumour cells enabling their regrowth.Taken together, these results show that the neutrophil attracting cytokines Cxcl1 and 2 are highly expressed in metastatic livers in response to gemcitabine withdrawal and this favours CXCR2-dependent recruitment of neutrophils at the hepatic metastatic site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GAS6 | up-regulates
binding
|
MERTK |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8939948 |
We also found that gas6 stimulated tyrosine phosphorylation of axl, sky, and mer receptors ectopically expressed in chinese hamster ovary cells. Taken together, these findings suggest that gas6 is a common ligand for axl, sky, and mer, all known members of an axl/sky receptor subfamily. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
GAS6 | up-regulates
binding
|
TYRO3 |
0.589 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34414 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7867073 |
We report the identification of ligands for tyro 3 (alternatively called sky, rse, brt, or tif) and axl (alternatively, ark or ufo), members of a previously orphan family of receptor-like tyrosine kinases. These ligands correspond to protein s, a protease regulator that is a potent anticoagulant, and gas6, a protein related to protein s but lacking any known function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIB | down-regulates quantity
transcriptional regulation
|
GAS6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268882 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | down-regulates quantity
transcriptional regulation
|
GAS6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268876 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
GAS6
- 
- 