| + |
PAX7 | up-regulates 
|
Quiescence |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135626 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15843801 |
We have identified a new cell population that expresses the transcription factors pax3 and pax7 (paired box proteins 3 and 7) but no skeletal-muscle-specific markers. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255366 |
|
|
|
|
| pmid |
sentence |
| 15501225 |
Our work presented here provides a possible mechanism involving Pax-7 that allow satellite cells to exit the cell cycle, down-regulate MyoD, and prevent myogenin induction, phenotypes characteristic of the quiescent satellite cell. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, |
| Tissue: |
Skeletal Muscle |
| Pathways: | NOTCH Signaling and Myogenesis |
| + |
RBPJ/NOTCH | up-regulates
|
Quiescence |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244004 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 22045613 |
Notch signaling is active in quiescent SCs. SC-specific deletion of recombining binding protein-J (RBP-J), a nuclear factor required for Notch signaling, resulted in the depletion of the SC pool and muscles that lacked any ability to regenerate in response to injury. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
3.0
Quiescence