| + |
RBPJ/NOTCH | up-regulates quantity by expression 
transcriptional regulation
|
HIF1A |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209720 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19808903 |
We report a Notch signal-induced pathway that leads to transcriptional activation of HIF1-alpha gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
NOTCH | form complex 
binding
|
RBPJ/NOTCH |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255363 |
|
|
|
|
| pmid |
sentence |
| 7566092 |
Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-Jk and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255377 |
|
|
|
|
| pmid |
sentence |
| 23729744 |
The released NICD translocates directly to the nucleus, where it forms a transcriptional complex with the DNA-binding protein CSL (CBF1, Suppressor of Hairless, Lag1), Mastermind (Mam) and transcriptional co-activators to drive the expression of Notch target genes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255380 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
Notch is cleaved and translocates to the nucleus, where it activates a family of transcription factors, exemplified by Suppressor of Hairless and CBF/RJBk |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255364 |
|
|
|
|
| pmid |
sentence |
| 22045613 |
NICD is translocated to the nucleus where it binds recombining binding protein-Jj (RBP-Jj) |
|
| Publications: |
4 |
| Tissue: |
Skeletal Muscle |
| + |
HES1 | down-regulates activity 
binding
|
RBPJ/NOTCH |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209756 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16682003 |
Here we show that hrt2 and hes1 interact with rbp-jkappa to negatively regulate notch-dependent activation of hrt and hes expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Heart |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling |
| + |
RBPJ/NOTCH | up-regulates 
|
Quiescence |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244004 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 22045613 |
Notch signaling is active in quiescent SCs. SC-specific deletion of recombining binding protein-J (RBP-J), a nuclear factor required for Notch signaling, resulted in the depletion of the SC pool and muscles that lacked any ability to regenerate in response to injury. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
RBPJ/NOTCH | down-regulates quantity by repression
transcriptional regulation
|
MYOD1 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219359 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10066785 |
Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
C2C12 Cell |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
RBPJ | form complex
binding
|
RBPJ/NOTCH |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255378 |
|
|
|
|
| pmid |
sentence |
| 23729744 |
The released NICD translocates directly to the nucleus, where it forms a transcriptional complex with the DNA-binding protein CSL (CBF1, Suppressor of Hairless, Lag1), Mastermind (Mam) and transcriptional co-activators to drive the expression of Notch target genes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255379 |
|
|
|
|
| pmid |
sentence |
| 12361602 |
Notch is cleaved and translocates to the nucleus, where it activates a family of transcription factors, exemplified by Suppressor of Hairless and CBF/RJBk |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209702 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21873209 |
When bound to the active intracellular domain of notch (nicd), rbpj recruits a coactivator complex, including a mastermind homologue (maml1-3 in mammals), and drives a complex transcriptional program with pervasive phenotypic effects. |
|
| Publications: |
3 |
Organism: |
, Homo Sapiens |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209590 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7566092 |
Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-J kappa (refs 8,9) and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HEY1 |
0.719 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170854 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21193018 |
Activated NICD-RBP-Jk complex displaces co-repressors and recruits coactivator (co-A) mediating the transcription of target genes such as Hes-1 (hairy enhancer of split), cyclin D, Hey-1 (hairy/enhancer-of-split related with YRPW motif) and others [1213]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
PAX7 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219365 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22493066 |
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells NICD regulates Pax7 through interaction with RBP-J_, which binds to two consensus sites upstream of the Pax7 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle, Satellite Cell |
| Pathways: | NOTCH Signaling and Myogenesis |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
NRARP |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113786 |
|
|
Homo sapiens |
Myoblast, T-lymphocyte |
| pmid |
sentence |
| 11783997 |
These observations demonstrate that the nrarp gene is an evolutionarily conserved transcriptional target of the notch signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
RBPJ/NOTCH | up-regulates quantity
transcriptional regulation
|
DUSP1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255744 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17158101 |
Our results show that Notch specifically induces expression of MKP-1, a member of the dual-specificity MAPK phosphatase, which directly inactivates p38 to negatively regulate C2C12 myogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | NOTCH Signaling and Myogenesis |
| + |
KDM5A | down-regulates
binding
|
RBPJ/NOTCH |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219250 |
|
|
Drosophila melanogaster |
T-lymphocyte |
| pmid |
sentence |
| 20231316 |
In this study, we show that the histone demethylase kdm5a associated with rbp-j protein and is essential for notch/rbp-j target gene silencing in vitro. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| Pathways: | NOTCH Signaling |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209593 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 16847353 |
C-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
CDKN1A |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252033 |
|
|
Mus musculus |
Keratinocyte |
| pmid |
sentence |
| 15866158 |
Induction of the p21WAF1/Cip1 gene by Notch 1 activation in differentiating keratinocytes is associated with direct targeting of the RBP-J_ protein to the p21 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NRARP | down-regulates
binding
|
RBPJ/NOTCH |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219228 |
|
|
Xenopus laevis |
|
| pmid |
sentence |
| 11485984 |
Overexpression of nrarp in embryos blocks notch signaling and inhibits the activation of notch target genes by icd. We show that nrarp forms a ternary complex with the icd of xnotch1 and the csl protein xsu(h) and that in embryos nrarp promotes the loss of icd. |
|
| Publications: |
1 |
Organism: |
Xenopus Laevis |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
NOTCH1 | form complex
binding
|
RBPJ/NOTCH |
0.95 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7566092 |
Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-Jk and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
PAX7 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255365 |
|
|
|
|
| pmid |
sentence |
| 22493066 |
Both binding sites were enriched by more than 5-fold in the ChIP assay with RBP-Jk antibody, suggesting that RBP-Jk occupies these sequences in the Pax7 promoter region. |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
| Pathways: | NOTCH Signaling and Myogenesis |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209753 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11486031 |
Using this inducible system, we show that Notchic activates transcription of the cyclin D1 gene with rapid kinetics. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
RBPJ/NOTCH