NOTCH Signaling and Myogenesis

Pathway ID: SIGNOR-NOTCH_Myogenesis View in NDEx

Description: Signaling induced by interaction between the receptor Notch and its ligand Delta plays an important role in cell fate determination in vertebrates. Notch signaling has emerged as a key player in skeletal muscle development and regeneration, where it inhibits muscle differentiation. Protein products of the Notch target genes repress transcription of pro-myogenic genes, activated by MyoD and Mef2C, through multiple mechanisms, including targeted repression by Hey1.

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19 Seed Entities

Organism:
Name Primary ID
HEY1 Q9Y5J3
gamma-secretase SIGNOR-C98
DLK1 P80370
ADAM17 P78536
RBPJ/NOTCH SIGNOR-C97
Skeletal_muscle_differentiation SIGNOR-PH1
MEF2C Q06413
DLL1 O00548
NUMB P49757
DTX1 Q86Y01
HES1 Q14469
MAPK14 Q16539
NOTCH1 P46531
Quiescence SIGNOR-PH25
MYOG P15173
MYOD1 P15172
NRARP Q7Z6K4
PAX7 P23759
DUSP1 P28562