| + |
CDKN1B | down-regulates 
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241967 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8033212 |
p27Kip1, a cyclin-dependent kinase inhibitor implicated in G1 phase arrest by TGF beta and cell-cell contact. p27Kip1 associates with cyclin E-Cdk2 complexes in vivo and in vitro, prevents their activation, and inhibits previously activated complexes, and p27Kip1 overexpression obstructs cell entry into S phase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267285 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDKN1A | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251564 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24470334 |
The cell cycle regulator p21 is induced early in myoblast differentiation and functions to block cell cycle progression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267283 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14976264 |
Sirt1 increased foxo3's ability to induce cell cycle arrest and resistance to oxidative stress |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RB1 | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267284 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21524151 |
Consistent with this, the magnitude of the response (i.e. the fraction of cells undergoing arrest) appears to diminish the closer the cells are to the time of S-phase entry. The existence of a time gap between full pRb phosphorylation and S-phase entry is also consistent with the notion that E2F, once released from pRb, transcriptionally activates factors needed for S-phase entry, a process which likely requires a significant amount of time. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBL2 | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241946 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10801445 |
Although forced expression of either p130 or pRb in mouse C2 myoblasts efficiently blocked cell cycle progression, only p130 inhibited the differentiation program. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BRCA1 | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267282 |
|
|
|
|
| pmid |
sentence |
| 15549093 |
The BRCA1 protein also contributes to cell-cycle arrest and DNA repair by homologous recombination |
|
| Publications: |
1 |
3.0
Cell_cycle_progress